Nitroxoline: instructions for use for cystitis in women

What is Nitroxoline?

The drug belongs to antibacterial and antiprosotic drugs used to eliminate problems associated with the genitourinary system.
It has a wide spectrum of action and can be used regardless of gender and age. The medication has a strong antimicrobial effect without harming internal organs and metabolic processes. The main active ingredient of the medicine is nitroxoline, which is mixed with:

lactose monohydrate;
wax;
povidone;
titanium dioxide;
calcium stearate.

Nitroxoline for cystitis is also used in preparing a patient for bladder surgery, preventing infections, and treating other pathologies:

urethritis;
thrush;
chlamydia;
prostatitis;
carcinomas;
prostate adenomas.

Analogues of the drug

Nitroxoline, like many other medicines, has similar drugs - synonyms and analogues . Synonym drugs are usually called those active agents that are produced on the basis of nitroxoline (a derivative of 8-hydroxyquinolone).

Medicines with similar effects include drugs based on similar substances, but with similar purposes and uses. Synonymous means include:

5-NOK;
5-Nitrox;
Nitroxoline-Acos;
Nitroxoline-UBF.

Analogues can be considered such means as:

Amizolid. The substance actively fights microbial effects on the body and eliminates them. Relieves inflammation and its symptoms.
Dixin. Can be used as a solution for oral and external use. Used to prevent inflammation of the urinary system and when using a catheter.
Zenix. Available in tablet form. Eliminates the inflammatory process and acts against the proliferation of microbes, having a detrimental effect on them.

Release form

The main form of release of the drug is coated tablets, packaged in 10 pieces. in blister packs, 5 per pack.

The drug is produced in tablets that have a biconvex round appearance and a yellow coating. They are in plates, 10 pieces each. One package can sell from 1 to 5 blisters.

Sometimes the medicine is available in pharmacies with the mark UBF, which indicates another manufacturer. This is the same medicine with the same composition, but a different color. It is no different from the original in terms of effectiveness.

The drug Nitroxoline for cystitis is available only in tablets that are taken orally. The shape is convex on both sides. A shell is applied on top, the color of which varies from light to dark shades of orange.

The tablets are packaged in blisters of ten. There can be 10, 25, 30, 40, 50, 100 pieces in a cardboard box. Instructions (abstract) are attached.

Active ingredient: nitroxoline, additional components:

magnesium stearate;
calcium hydrogen;
corn starch;
gum arabic;
yellow quinodine.

The tablets are coated with an orange coating.

Reception scheme

Tablets are taken up to 4 times a day, with equal time intervals between doses (6 – 8 hours). The therapeutic course lasts from 10 days to 2 weeks. For chronic inflammation with frequent recurrent exacerbations, you need to drink Nitroxoline for several months.

The tablets are taken whole during meals, washed down with a large volume of water. It is not advisable to take Nitroxoline on an empty stomach, since in this case the likelihood of developing digestive disorders (nausea, diarrhea, vomiting) increases.

For adults, the daily dosage ranges from 600 mg to 800 mg. Children's daily doses are calculated from the ratio: per kilogram of child weight 0.010–0.030 g of active substance. Children over five years of age are allowed to take no more than 400 mg per day, adults - up to 1200 mg.

The dosage must be observed when taking the drug

Pharmacological action and pharmacokinetics

Nitroxoline tablets have an antibacterial effect.

This drug is an antibacterial agent, a derivative of 8-hydroxyquinoline. Its action is due to the selective inhibition of bacterial DNA production. The activity of Nitroxoline is manifested against known gram-positive bacteria and gram-negative bacteria, and some types of fungi.

As a result of oral administration, Nitroxoline-UBF is absorbed from the gastrointestinal tract to a fairly high degree. Excretion occurs through the kidneys, almost unchanged. In this case, high concentrations of the main substance are predominantly determined in the urine.

The main task of the main active ingredient is to eliminate the cause that led to the development of the pathology and prevent the deterioration of the condition. It prevents the proliferation of harmful microorganisms that cause inflammation of the bladder. A special enzyme complex prevents an increase in the number of pathogenic bacteria, while simultaneously creating conditions unfavorable for the life of the remaining microbes. It has no effect on healthy cells of the body.

30 minutes after taking the tablets dissolve in the gastrointestinal tract, and the substances they contain spread throughout the body. The maximum concentration of the drug is observed after 2 hours. The main components are processed by the liver. The effect lasts about 3 hours.

Composition and action of Nitroxoline

The medicine is made on the basis of the active substance – nitroxoline, which belongs to the class of oxyquinolines. One tablet contains 50 mg of active substance. Additional components included in Nitroxoline include: sugar contained in plants, low molecular weight polyvidone, colloidal class double silicon oxide, talc, double titanium oxide with coloring properties, beeswax, dye 85 E 110, waxy hydrocarbon mixture, as well as some other substances.

The action of the active substance is based on preventing the synthesis of bacteria by suppressing their deoxyribonucleic acids. After a short period of time, cells harmful to the body become unable to reproduce and begin to gradually die. Nitroxoline has a destructive effect on gram-negative and gram-positive bacteria, parasitic fungi, microbacteria and trichomonas. The drug has high absorption properties and, when excreted from the body through the kidneys, retains its original type. As a result, a high dose (from 100 μg/ml) of the concentrate is observed in the urine.

Adverse reactions

If treatment with this medication is carried out for a long period of time, then negative consequences occur for the human body. Typically, such side effects are characteristic of the gastrointestinal tract and nervous system.

Patients often encounter the following:

they begin to feel sick;
vomiting becomes a big problem, with a large amount of vomit observed;
appetite decreases;
severe headache and dizziness;
worries about tachycardic conditions;
the liver works intermittently;
polyneuropathic reactions are observed;
jumps in blood pressure cause concern;
the temperature rises.

In addition, these tablets against cystitis cause various allergic reactions, which causes a red, pinpoint-sized rash to appear all over the body, and the skin begins to itch and itch.

If contraindications are ignored or there are unknown health problems, an unexpected effect may occur, resulting in:

Dyspeptic disorders:
nausea and vomiting;
feeling of heaviness in the bladder;
loss of appetite;
heartburn.
Headaches and dizziness.
Various allergic reactions:
anaphylactic shock.
Decreased visual abilities (with optic nerve neuritis).
Pain in peripheral muscles.
Paresthesia:
decreasing or increasing sensitivity.
Tachycardia.

The drug has a neurotoxic effect, creating the likelihood of developing subacute neuropathy. For this reason, flaccid paralysis, tactile and autonomic disturbances may occur.

Each person reacts individually to nitroxoline, and most disorders are associated with the gastrointestinal tract. Changes in the functioning of the digestive system are often dose-dependent and therefore disappear immediately after stopping treatment. It is strictly forbidden to drink alcohol, as it does not combine well with the substance, causing dyspeptic symptoms and myalgia.

Nitroxoline for cystitis: treatment, how to take

Bladder inflammation is a common problem caused by bacterial or non-infectious factors. Most often, this disease occurs in women, but men also often suffer from it. Nitroxoline for cystitis allows you to quickly and effectively eliminate symptoms, neutralizing the causes of the disease.

What is Nitroxoline?

The drug belongs to antibacterial and antiprosotic drugs used to eliminate problems associated with the genitourinary system. It has a wide spectrum of action and can be used regardless of gender and age. The medication has a strong antimicrobial effect without harming internal organs and metabolic processes.

The main active ingredient of the medicine is nitroxoline, which is mixed with:

lactose monohydrate;
wax;
povidone;
titanium dioxide;
calcium stearate.

Nitroxoline for cystitis is also used in preparing a patient for bladder surgery, preventing infections, and treating other pathologies:

urethritis;
thrush;
chlamydia;
prostatitis;
carcinomas;
prostate adenomas.

Release forms

The drug is produced in tablets that have a biconvex round appearance and a yellow coating. They are in plates, 10 pieces each. One package can sell from 1 to 5 blisters.

Pharmacological action and pharmacokinetics

the task of the main active substance is to eliminate the cause that led to the development of the pathology and prevent the deterioration of the condition.

It prevents the proliferation of harmful microorganisms that cause inflammation of the bladder.

A special enzyme complex prevents an increase in the number of pathogenic bacteria, while simultaneously creating conditions unfavorable for the life of the remaining microbes. It has no effect on healthy cells of the body.

Contraindications for use

Treatment of cystitis with Nitroxoline can be harmful in some cases. The elements contained in its composition will aggravate the health condition when:

individual intolerance;
severe decompensated liver damage;
chronic insufficient kidney function and diseases accompanied by urinary disorders;
cataracts;
Do not lie;
inflammation of the peripheral nervous system;
pregnancy;
lack of glucose-6-phosphate dehydrogenase, which leads to difficulties with the formation of red blood cells.

The drug may be used strictly as prescribed by a doctor. When using independently, checking the restrictions specified in the instructions is mandatory.

Adverse reactions

If contraindications are ignored or there are unknown health problems, an unexpected effect may occur, resulting in:

Dyspeptic disorders:
nausea and vomiting;
feeling of heaviness in the bladder;
loss of appetite;
heartburn.
Headaches and dizziness.
Various allergic reactions:
anaphylactic shock.
Decreased visual abilities (with optic nerve neuritis).
Pain in peripheral muscles.
Paresthesia:
decreasing or increasing sensitivity.
Tachycardia.

The drug has a neurotoxic effect, creating the likelihood of developing subacute neuropathy. For this reason, flaccid paralysis, tactile and autonomic disturbances may occur.

Each person reacts individually to nitroxoline, and most disorders are associated with the gastrointestinal tract. Changes in the functioning of the digestive system are often dose-dependent and therefore disappear immediately after stopping treatment. It is strictly forbidden to drink alcohol, as it does not combine well with the substance, causing dyspeptic symptoms and myalgia.

Drug incompatibility

Nitroxoline helps with cystitis, but it is not compatible with some medications:

With regular use of antacids prescribed for the healing of gastritis and ulcers, its effectiveness is significantly reduced, since they contain components that reduce bioavailability.
Medicines belonging to the group of hydroxyquinolines, which are prescribed to destroy protozoal infections, do not combine well with the drug, so their general use is prohibited.
Tablets reduce the effectiveness of nalidixic acid, used as an antibacterial agent.

Also, if a person has a urogenital disease and uses nitrofurans, the use of tablets with nitroxoline is not recommended. Its dosage changes or is completely limited when used:

tetracycline antibiotics – reduced by 50%;
nitrofurans - prohibited to avoid harm to the nervous system;
antacids - absorption worsens;
hydroxyquinolines – completely excluded;
nystatin and levorin - the reaction may increase.

Efficiency in inflammation of the bladder

The drug is not on the list of medications recommended for the treatment of this problem. This is due to poor tolerance of the main active ingredient. Most patients had gastrointestinal disorders and neurological symptoms. Therefore, the medication was gradually replaced by furagin.

Also, there are no multicenter studies to determine the effect of the drug on genitourinary tract infections. For this reason, it is prescribed in cases where more popular analogues have not had the desired effect or are not available for sale.

Currently, Western medicine is conducting experiments on the use of nitroxoline for chemotherapy and cancer due to its moderate cytotoxic effect.

Tablets for cystitis are inexpensive and effective for women as a quick treatment, recommendations

How to take for cystitis

Use is carried out under the supervision of a general practitioner or urologist. The minimum duration of treatment is 5 days. The daily dose of the main active ingredient is 400 mg. You need to take 2 tablets every 6 hours 4 times a day.

In difficult cases, the dosage is doubled. If the patient has chronic pathologies of the liver and kidneys, the daily dose is reduced to 200 mg. If there is inflammation of the bladder in a child over 3 years of age, the daily dose should not exceed 50 mg.

During treatment, the doctor monitors the effectiveness of the medication, evaluates clinical symptoms, and conducts bacteriological urine tests. The maximum duration of continuous use is 4 weeks. People who do not know how to take nitroxoline for cystitis are recommended to use the instructions that follow in the package.

special instructions

The dosage must be changed if moderate or moderate renal dysfunction is detected. This disease can make it difficult to remove components from the body, which is why they will accumulate in the blood and gradually provoke intoxication.

Studies on the effects of the drug on the fetus during pregnancy have not been conducted, so pregnant women should first consult a doctor. The tablets are prohibited in the early stages and 10 weeks before birth, although no negative effects on the embryo during use have been recorded.

If the previously listed side effects are detected, it is necessary to perform gastric lavage using absorbents (activated carbon or enterosgel). After use, it is not recommended to drive a car or engage in other work requiring increased attention.

Reviews from doctors

Experts in the field of urology indicate that nitroxoline helps with cystitis in most cases. It is prescribed not only after the disease is detected, but also during exacerbation. Before use, you should take a urine test for bacterial culture. The main advantages of the drug, according to doctors, are:

quick effect (just 20 minutes after use);
low cost;
destination possibilities? both women and men.

Patient reviews

Almost all opinions of people who have used the medicine are positive. However, there are comments that nitroxoline does not help with cystitis, and after its use, adverse reactions occur. Therefore, it is recommended to take it strictly under the supervision of specialists who can individually check how effective it is for each patient.

Analogues in composition

There are domestic and Western analogues on the medical drug market with a similar composition:

Russian (Nitroxoline-AKOS and UBF);
Slovenian (5-NOK);
American (5-Nitrox).

When using the options listed, it is necessary to check the dosage as it may vary.

Medicines for cystitis: a review of antibiotics

Substitutes by principle of action

To treat inflammation of the bladder, other medications that act in a similar way are prescribed:

Furamag, furagin, furasol (based on nitrofuran). Prescribed when an acute form of the disease occurs. The main advantage is rare side effects. The minimum duration of use is 3 days. Reviews of people who have used nitroxoline for cystitis indicate that these drugs are well tolerated by patients, but are not recommended if there are diseases of the kidneys, respiratory system, or diabetes.
Monural, forfural (based on fosfomycin). They are used if inflammation of the bladder is associated with Escherichia coli, Proteus, Klebsiella. Effective in eliminating urogenital infections.
Penicillins. Quickly and effectively destroy bacterial pathogens. Prescribed by doctors in the field of urology if nitroxoline for cystitis does not give the desired result.
Fluoroquinols. They block the DNA gyrase enzyme, which leads to the death of pathogenic pathogens. During pregnancy and breastfeeding - prohibited.

Making an appointment with a urologist

If you want to consult about the use of medications for urological diseases, make an appointment with a qualified doctor.

Source: https://kurology.ru/zabolevanie/nitroksolin-pri-cistite/

Indications for use

Nitroxoline is used for the treatment and exacerbation of cystitis, and is also prescribed for:

urethritis;
pyelonephritis;
adenoma;
epididymitis.

For preventive purposes, it is recommended during surgical interventions.

The medicine should not be taken if the patient:

renal failure;
hypersensitivity to the drug;
liver diseases;
cataract;
neuritis;
deficiency of glucose-6-phosphate dehydrogenase;
polyneuritis.

Main indications for use of Nitroxoline:

treatment of infectious and inflammatory diseases of the genitourinary tract, for example: pyelonephritis, cystitis, urethritis, epididymitis, infected adenoma or prostate carcinoma;
carrying out the prevention of infectious complications during diagnostics and treatment procedures - catheterization or cystoscopy, as well as after or during operations in the area of the kidneys and genitourinary tract.

Taking tablets is not recommended if:

impaired renal function, which may be accompanied by oligo- or anuria;
severe liver diseases;
deficiency of glucose-6-phosphate dehydrogenase;
neuritis;
cataracts;
pregnancy, lactation;
high sensitivity to quinolines.

The drug has a number of contraindications, so it is taken only under the supervision of a specialist. The medication is contraindicated for certain categories of citizens who are prescribed more gentle medications. Nitroxoline is not recommended for the treatment of pregnant women, as it negatively affects not only the health of the mother, but also the condition of the fetus.

You should not be treated with medication while breastfeeding a child in order to reduce the risk of the appearance and development of pathological conditions in the child.

Indications for the use of Nitroxoline are the treatment of urinary tract pathologies that are infectious and inflammatory in nature. Categories containing information on what Nitroxoline helps with include:

Nonspecific inflammatory diseases of the kidneys of bacterial etiology, characterized by damage to the renal pelvis, calyces and kidney parenchyma.
Inflammatory processes in the area of the bladder and urethra.
Inflammation of the epididymis that occurs against the background of a pre-existing infectious disease.
Benign prostate tumors
Malignant tumors of the infectious type of the prostate gland.

Nitroxoline can be used for cystitis not only for treatment, but also for preventive purposes. If the body has been subjected to a catheter being inserted into the bladder, then this remedy is ideal for prevention. Prevention is also carried out using Nitroxoline tablets when diagnosing bladder diseases using the endoscopic method.

The drug is contraindicated for people suffering from renal failure, severe liver pathologies, clouding of the eye lens, inflammation of peripheral nerves, multiple nerve damage, lack of glucose, as well as individual intolerance to the drug. In some cases, for example, during pregnancy and lactation, the medication is contraindicated, but not for everyone.

In some cases, the following side effects are observed: nausea, gag reflexes and decreased appetite. Slightly less common are allergic reactions on the skin. Rapid heartbeat, poor coordination of movements, deterioration of kidney function and severe headaches are also side effects of Nitroxoline, but they occur in isolated cases.

Typically, treatment of cysts with Nitroxoline is tolerated normally, without causing severe side effects. But in this case, you should not self-medicate. Only a doctor can make an accurate diagnosis and select the correct dosage based on instrumental and laboratory tests.

The medicine is prohibited for use if the patient has:

neuritis,
polyneuritis,
renal and heart failure,
cataract,
intolerance to components,
lack of glucose-6-phosphate dehydrogenase,
advanced liver pathologies.

Treatment of cystitis with Nitroxoline can be harmful in some cases. The elements contained in its composition will aggravate the health condition when:

individual intolerance;
severe decompensated liver damage;
chronic insufficient kidney function and diseases accompanied by urinary disorders;
cataracts;
Do not lie;
inflammation of the peripheral nervous system;
pregnancy;
lack of glucose-6-phosphate dehydrogenase, which leads to difficulties with the formation of red blood cells.

The drug may be used strictly as prescribed by a doctor. When using independently, checking the restrictions specified in the instructions is mandatory.

Are there any side effects?

The medicine is not addictive in adults, but has a negative effect on hormonal levels. When treating cystitis, you must strictly follow the doctor’s recommendations and do not use the drug for too long. It has a number of side effects affecting the immune, cardiovascular, digestive, and nervous systems of the human body.

The main consequences of taking Nitroxoline:

tachycardia,
polyneuropathy,
headache,
disorders of the liver,
rash on the body, accompanied by itching,
redness of the skin (hyperemia),
poor appetite
vomiting, nausea,
dizziness, weakness,
loss of coordination of movements (ataxia),
paresthesia (pins and needles).

The patient's urine may take on a reddish tint. After long-term use, atrophy of the optic nerve (optic neuropathy) is observed.

You should not cause cystitis or self-medicate. Properly selected therapy will help you recover quickly and avoid negative consequences.

Drug incompatibility

Nitroxoline helps with cystitis, but it is not compatible with some medications:

With regular use of antacids prescribed for the healing of gastritis and ulcers, its effectiveness is significantly reduced, since they contain components that reduce bioavailability.
Medicines belonging to the group of hydroxyquinolines, which are prescribed to destroy protozoal infections, do not combine well with the drug, so their general use is prohibited.
Tablets reduce the effectiveness of nalidixic acid, used as an antibacterial agent.

Also, if a person has a urogenital disease and uses nitrofurans, the use of tablets with nitroxoline is not recommended. Its dosage changes or is completely limited when used:

tetracycline antibiotics – reduced by 50%;
nitrofurans - prohibited to avoid harm to the nervous system;
antacids - absorption worsens;
hydroxyquinolines – completely excluded;
nystatin and levorin - the reaction may increase.

Use of the drug during pregnancy and lactation

It should be noted that doctors still prescribe Nitroxoline during pregnancy, but only if the risks from using the medication are less than the danger of cystitis for the health of the expectant mother. The medicine is strictly prohibited in the last 10 weeks of pregnancy in women, since during this period the body is especially sensitive. During lactation, the harmful components of Nitroxoline can penetrate into the milk and cause poisoning in the child's body. Therefore, the medication can only be used with the permission of a doctor.

Side effects

Currently, Western medicine is conducting experiments on the use of nitroxoline for chemotherapy and cancer due to its moderate cytotoxic effect.

Tablets for cystitis are inexpensive and effective for women as a quick treatment, recommendations

In most cases, the development of side effects occurs when patients take the drug without even knowing what the pills help with. In this case, there may be deviations in the functioning of the digestive system, for example, nausea, vomiting, loss of appetite, and sometimes disturbances in the functioning of the liver.

Allergic reactions such as skin rash and itching may occur.

Somewhat less frequently, disturbances in the activity of the nervous system occur, manifested by ataxia, headache, paresthesia, and polyneuropathy. Long-term use can cause optic neuritis.

In general, as you know, Nitroxoline is an antibiotic, so undesirable effects affecting the functioning of various organs and systems, including the cardiovascular system, cannot be ruled out.

The positive effect of the drug occurs if all the doctor’s instructions are strictly followed. After the tablet enters the body, the active component is absorbed from the gastrointestinal tract and accumulates in large quantities in the patient’s urine. Therefore, Nitroxoline has a strong healing effect on the organs of the urinary system. The drug is quickly absorbed, which determines the early therapeutic effect.

Although Nitroxoline has shown good compatibility with other medications, it is better to consult with your doctor before taking it in parallel. It enhances the effect of certain medications, but there are drugs that completely block its effect, making it completely useless.

Nitroxoline for cystitis: how to take, reviews

Cystitis is an inflammatory lesion of the bladder, which is bacterial or non-infectious in nature. It occurs more often in women, since they have a special structure of the genitourinary system.

But in men, pathology is no exception. The disease must be treated. Various drugs are used for this.

You should take Nitroxoline for cystitis only if it is caused by bacteria, microbes or fungus.

Analogues and substitutes

The price of the tablets is not too high - from 69 rubles. If the drug does not help properly or causes side effects, it can be replaced. There are different analogues of the drug: according to the main substance or mechanism of action.

The list of substitutes includes: “Nibiol”, “Nitroxoline UBF”, “Nikopet”, “Noxibiol”, “Niuron”, “Noxin.”

How does it work for cystitis?

For cystitis, treatment with Nitroxoline helps to quickly get rid of the pathology and prevent its further development. The product suppresses the proliferation of pathogenic microorganisms due to the presence of a special enzyme complex.

If you block the ability of bacteria to multiply, then after a short period of time they die. The drug affects only pathogenic microorganisms without affecting healthy cells.

The product is quickly absorbed into the gastrointestinal tract, within half an hour. A high concentration of the main active substance is observed in the urine after 2 hours. It lasts up to 3 hours. The drug is metabolized in the liver.

For the treatment of cystitis resulting from an infection of the prostate or bladder, Nitroxoline is one of the most effective remedies. It is prohibited to stop taking the drug or change the duration of treatment on your own.

Side effects

Treatment with medications is sometimes accompanied by side effects. Nitroxoline can also cause them.

Here is a list of the main negative reactions of the body:

indigestion, nausea and vomiting, sometimes liver problems;
skin rash, itching or other allergic manifestations;
change in heartbeat;
impaired skin sensitivity, gait problems;
problems with coordination, loss of balance;
optic nerve neuritis;
headache.

Nitroxoline is less toxic than other antibacterial drugs. But you need to use it correctly, strictly according to the instructions and prescription of the doctor.

Directions for use and doses

According to the instructions for use of Nitroxoline-UBF, the tablets are taken orally, preferably after meals. The dosage of the drug is determined by the attending physician. On average, adult patients are prescribed 0.1 g per day, 4 times a day. In this case, the duration of treatment can be 2-3 weeks.

If necessary, repeat courses are given after 2 weeks. The tablets are also prescribed to prevent postoperative infections in the kidney or urinary tract, and it is recommended to take 0.1 g of the drug 4 times a day for 2-3 weeks.

Cases of drug overdose may be accompanied by symptoms such as vomiting, nausea or general weakness. Treatment includes gastric lavage, taking enterosorbents and symptomatic therapy.

The dosage is individual for each patient. If cystitis appears for the first time, it is recommended to take 2 tablets 4 times a day. There is an interval of 6 hours between doses. If you feel relief, you should not stop therapy until the tests are normal.

For chronic diseases of the genitourinary system, the drug is used according to the same scheme. But if after 2 days there is no relief, then you need to increase the dose to 4 tablets at a time. Side effects Sometimes Nitroxoline causes side effects. Uncontrolled use of the drug can cause:

nausea;
vomiting;
decreased appetite;
migraine;
tachycardia;
problems with liver function;
polyneuropathy.

Sometimes courses of taking Nitroxoline lead to allergic reactions, which manifest themselves in the form of itching and rashes on the epithelium.

In case of drug overdose the following is observed:

tachycardia;
nausea;
vomiting;
skin rashes;
headache.

If such symptoms appear, you need to stop taking Nitroxoline for 3-4 days.

Antimicrobial agents Nitroxoline - review

Good day, dear readers.

I am familiar with such an unpleasant sore as cystitis firsthand. Unfortunately, this disease has long become chronic for me and periodically bothers me.

I’ll say right away that I don’t run to doctors after each new exacerbation, but treat myself. I have a treatment regimen that was given to me in the hospital when I was in the nephrology department. True, I was lying there with a diagnosis of acute kidney pyelonephritis.

Pyelonephritis is a kidney disease that is infectious and inflammatory in nature. The disease develops as a result of the spread of pathogenic microorganisms that penetrate the kidneys from the lower parts of the urinary system.

If pathogenic bacteria invade its lower sections, and antibacterial therapy is chosen incorrectly or is completely absent, then the microorganisms begin to rapidly multiply and spread to the kidneys.

This leads to symptoms of pyelonephritis.

That is, I developed cystitis, and it caused complications on the kidneys. Therefore, you should not treat cystitis as a mild illness that can be “silenced” with drugs. Any treatment should be selected by a nephrologist. It was after treatment in the hospital that I became acquainted with such drugs as Nitroxoline, Canephron N, Nolitsin, Monural and others, which I successfully use for exacerbations of cystitis.

So, the hero of our review is the drug Nitroxoline.

Nitroxoline instructions for use price reviews

Release form: coated tablets. coated, 50 mg: 50 pcs.

Manufacturer: Anzhero – Sudzhensky chemical and pharmaceutical plant

Active ingredient: Nitroxoline (Nitroxoline)

PRICE OF NITROXOLINE.

I can say with confidence that Nitroxoline tablets are one of the most inexpensive drugs for the treatment of cystitis. Their price varies from 40 to 80 rubles for 50 tablets. In our pharmacies I buy them for only 50 rubles. This is very beneficial since the average course of treatment ranges from 10 days to 3 weeks.

Nitroxoline instructions for use price reviews

INSTRUCTIONS FOR USE OF NITROXOLINE

Nitroxoline instructions for use reviews

NITROXOLINE. MY USE FOR CYSTITIS

The tablets are small, orange in color. Swallow easily. I wash them down with plenty of regular boiled water.

Nitroxoline application reviews

The amount of liquid drunk during treatment should be at least 1.5-2 liters, since pathogenic organisms are washed out more quickly from the walls of the bladder. Of course, if you have cystitis in a very acute form with painful and frequent urination, drinking a lot of fluid can be extremely difficult.

For myself personally, I have developed the following scheme: at the very beginning of the disease, when I have severe pain when urinating, plus it is quite frequent, I drink 3 Nitroxoline tablets at once, washed down with a small amount of water.

(one small glass). After about 5 hours I take 2 more tablets. After 5 tablets, acute attacks of cystitis stop, and then I start drinking a lot of fluids.

In this case, frequent trips to the toilet do not cause discomfort.

I have been drinking nitroxoline for about 10 days strictly according to the instructions, i.e. about 400 mg per day, which is 8 tablets. My very first acute symptoms disappear after using 5-6 tablets. On the second day I usually forget about such an unpleasant sore as cystitis.

Nitroxoline application reviews

I always carry out the course of treatment to the end, since more than once there has been a situation when I took pills only on the first day of the disease and the cystitis returned a day later, since it remained untreated.

ANALOGUES OF NITROXOLINE.

Complete analogues of Nitroxoline include the following drugs: 5-Nitrox, 5-NOK, Uroxoline, Nitroxoline-UBF. If nitroxoline is not available, I most often buy 5-NOK. The action is absolutely identical, although the price is 2 times higher.

WHEN NITROXOLINE DID NOT HELP...

Honestly, this happened to me only once. In the summer I had a very acute exacerbation of cystitis. The pain was simply unbearable. Taking nitroxoline provided only superficial relief from the symptoms; after a while they returned again with a vengeance.

Then I called my gynecologist, she advised me to take the antibiotic Monural, and then complete treatment with the drug Canephron N. Monural was not available in the pharmacy, but the pharmacist advised me of its cheaper analogue. (you can read a review of this drug here).

This situation only happened once. Therefore, I’m deducting one point from the drug nitroxoline. Still, nitroxoline is not an antibiotic, but an antimicrobial drug, so it will not help in all cases.

You might be interested:

Excellent vitamins for hair loss for 150 rubles TYK

A budget painkiller, approved even for nursing mothers. HERE

A complete analogue of Nitroxoline, but a little more expensive 5 NOK (plus a useful LIFEHACK for the prevention of cystitis!)

Treatment of cystitis with the antibiotic FOSFORAL (a cheaper analogue of MONURAL!)

Tired of thrush? I recommend excellent cheap CANDLES

Source: https://irecommend.ru/content/zamuchal-khronicheskii-tsistit-moya-skoraya-pomoshch-nitroksolin-polnaya-instruktsiya-po-pri

Efficacy in the treatment of cystitis

Many patients are often interested in how to properly take Nitroxoline for cystitis. General recommendations for taking the drug can be found in the instructions for use. But the doctor must prescribe the exact daily and single dosage. It will take into account the individual characteristics of the body, the patient’s age, the form of the disease and the pathologies already existing in the patient’s body.

You can drink Nitroxoline both before and after meals. The daily dosage for adults ranges from 400 to 800 mg. This dose should be evenly distributed into 3 doses per day. And the time intervals between taking the medication should be at least 6 hours. The duration of treatment for cystitis is two to three weeks. Even if the painful symptoms of cystitis have disappeared, you should continue to take the medicine until your urine levels return to normal.
For infectious diseases of a chronic nature that affect the urinary tract, it is recommended to take the drug for 14 days. After undergoing drug therapy for 2 weeks, you should take a break for the same number of days, and then continue treatment again. But the daily dose must be reduced to 200 mg per day, divided into 3-4 doses.
Rules for use for children depend on the age category of the child. The dosage of the drug for children under 5 years of age is 0.2 grams. This dose should be divided into 4 equal doses. Children over 5 years old are allowed to consume - from 0.2 to 0.4 g.
When using tablets for preventive purposes, 0.4 grams of the drug per day is prescribed for adults and from 10 to 30 mg/kg for children. It is recommended to divide the dose into 4 times. The course of treatment ranges from 14 to 21 days.

What to remember before taking: contraindications and side effects

Nitroxoline is contraindicated for people with the following diseases:

renal failure;
liver in severe or acute forms;
cataracts;
neuritis.

In addition, the drug should not be used if allergic reactions or individual intolerance to substances included in the product occur.

The use of Nitroxoline in rare cases is accompanied by nausea or vomiting, which can lead to loss of appetite. Skin irritations, coordination problems, migraines, and neuritis may also appear.

special instructions

The dosage must be changed if moderate or moderate renal dysfunction is detected. This disease can make it difficult to remove components from the body, which is why they will accumulate in the blood and gradually provoke intoxication.

How to use the drug correctly

Before starting to take the drug, you should consult your doctor.

When treating acute cystitis, the medication must be taken 4 times a day for 2 weeks. The interval between taking the drug should be at least 6 hours.

After eliminating the symptoms of the disease, it is necessary to continue taking the medication until the urine test results are normalized.

If the medication is used to treat a chronic form, then it should also be taken 4 times a day. The maximum daily dose of tablets is 20. If the use of the drug does not bring the desired results, then the course of taking it is extended to 3 weeks.

If the tests do not return to normal, the specialist may prescribe a two-week break, after which it will be necessary to continue treatment.

The medication is a small yellow coated tablet. They must be taken orally. It is best to take this medication during meals or immediately after. Nitroxoline should be taken with a small amount of liquid.

This drug interacts with alcohol for quite a long time. It is best to consult a specialist when determining the volume of the drug. The doctor will determine the required dosage based on the general condition of the body and the form of the disease.

When taking Nitroxoline, your urine may change color. It may take on a yellow-red or orange tint. This reaction is completely natural for the body. Reviews confirm this reaction of the body to the pills.

Reviews from doctors

As reviews of Nitroxoline show, many patients use this drug for cystitis. It should be noted that this remedy is well known to women. However, some of them are interested in Nitroxoline tablets - what they are for and how to take the medicine correctly.

In most cases, reviews of Nitroxoline for cystitis confirm the fairly high effectiveness of these tablets. But there are also reports when the medicine did not help quickly eliminate the unpleasant symptoms of the disease.

There are especially frequent discussions about how to take Nitroxoline during pregnancy, although its use is contraindicated during this period. However, sometimes women wonder whether these pills can be taken during pregnancy, and what the consequences might be? At the same time, experts do not recommend self-medication, and if symptoms of the disease appear, immediately consult a doctor.

Sometimes this medicine is prescribed to children, but most parents, after carefully studying the annotation, doubt whether patients can take the pills at an early age. They also find out whether Nitroxoline is an antibiotic or not, and at what age is it prescribed for cystitis?

Experts recommend that before starting to take these tablets, get tested and find out how sensitive the pathogen microorganisms are to the effects of this antibiotic. Thanks to this, you can understand how effective this treatment will be.

Until patients receive test results, taking antibiotics is not recommended. But you can use local antimicrobial agents, not forgetting to drink plenty of fluids, for example, herbal decoctions.

In addition, you should discuss possible replacement options with your doctor, and if this drug is not suitable for treatment, find out how you can quickly find an effective treatment. Only with this approach can we hope that health will be restored fully and in a short time.

On the pharmaceutical market, the medicine is available in tablet form. Each tablet contains 50 mg of active substance. How to take nitroxoline when sick? A similar question often worries patients who are prescribed pills. Instructions for use for cystitis recommend that an adult consume 600-800 mg per day. The amount of active substance is divided by 4 times.

If the use of the drug does not lead to relief, the course period is increased to three weeks. The remedy is especially effective in women: it eliminates all symptoms of the disease, even if it is chronic in a short period of time.

How much you drink it, in what dosage, as well as the timing of treatment are established by a medical specialist as a result of the examination. If the disease has not been cured after its use, the specialist advises taking a 2-week break, and then you should take the recommended medications again.

When using the drug, there is no decrease in its properties when using alcoholic beverages in small quantities.

Before using Nitroxoline, it is recommended to read the instructions for use. Self-treatment should not be carried out. The dosage and duration are prescribed by the urologist, based on the patient’s age, concomitant diseases, the severity of cystitis, and the individual characteristics of the body.

Getting rid of cystitis with Nitroxoline depends on the form of the disease:

Acute cystitis that appeared for the first time. Take 2 tablets every six hours. There should be four appointments in total per day (for example, morning - 6.00, lunch - 12.00, evening - 18.00, night - 24.00). The duration of therapy is about two weeks. It is important not to interrupt the course even after the symptoms disappear. At the end of the therapeutic period with Nitroxoline, you need to take three tests in a row and, if they are in order, then the treatment was successful.
Chronic cystitis. In case of exacerbation of the disease, two Nitroxoline tablets are prescribed 4 times a day. Reception is carried out at equal time intervals. If this method does not give a positive result, the dosage is increased to three pieces (the maximum you can take is 6 tablets at a time, and 20 per day). Treatment period is at least 3 weeks. Then you need to undergo an examination. If the tests are far from normal, a break is taken for 14 days and the Nitroxoline course is repeated.

To reduce the unpleasant symptoms (nausea and vomiting) caused by Nitroxoline, it is recommended to take it with meals. The tablets should not be chewed; they should be swallowed whole with plenty of water.

The drug is used to get rid of cystitis in children. In this case, the dosage is selected individually. The guide provides a daily dose of 10–30 mg of active ingredient per kilogram of body weight. There should be 3-4 doses per day at regular intervals. Children under five years old can take up to 8 tablets per day (400 mg), and children from 5 to 15 years old can take 12–16 tablets, which is 600–800 mg. The optimal dose is selected at which side effects do not appear and the child recovers. Duration of therapy is 10–21 days.

quick effect (just 20 minutes after use);
low cost;
destination possibilities? both women and men.

If you want to consult about the use of medications for urological diseases, make an appointment with a qualified doctor.

Nitroxoline for cystitis: instructions for use and reviews

Nitroxoline is a drug with an antimicrobial effect, active against many bacteria and microbes. Nitroxoline is often prescribed for cystitis and other infections of the genitourinary system. Cystitis in men: causes, symptoms and treatment.

Instructions for use

The drug Nitroxoline - instructions for use of the antimicrobial drug are presented for informational purposes. Be sure to consult your doctor before taking this medication.

pharmachologic effect

The drug Nitroxoline has a strong antimicrobial effect, thanks to which it destroys pathogenic microorganisms that provoke infectious processes in the urinary tract.

The active substance of the drug blocks the synthesis of nucleic acids (DNA) of microbial cells due to the formation of enzyme complexes that ensure the entire process. As a result of the blockage, germs cannot reproduce. Without reproduction, the microbial cell lives only a short time and dies.

Nitroxoline acts selectively; the drug does not have a negative effect on human cells, unlike antibacterial drugs.

The drug Nitroxoline is active against the following microorganisms:

staphylococci;
streptococci;
diphtheria bacillus;
gonococcus;
coli;
Proteus;
Klebsiella;
salmonella;
shigella;
enterobacteria;
Mycobacterium tuberculosis;
Trichomonas;
fungi of the genus Candida;
dermatophyte fungi;
mold fungi.

The above list indicates the wide spectrum of action of the drug Nitroxoline. Most often, the drug is prescribed for the treatment of infections of the genitourinary organs - cystitis, urethritis, pyelonephritis, but it is also advisable to use it for the treatment of infections of any type - bronchitis, pneumonia, infectious prostatitis and so on.

Nitroxoline tablets, when taken internally, are quickly absorbed into the blood, the active substance of the drug is excreted by the kidneys along with urine in a completely unchanged form. The accumulation of high concentrations of the drug occurs in the urine, due to which Nitroxoline is considered the most effective drug for the treatment of infectious and inflammatory processes of the genitourinary organs.

Composition and release form

The drug Nitroxoline is available in the form of tablets for internal use. Nitroxoline tablets are coated from yellow-orange to orange, biconvex, three layers are visible when cut through the tablets. The medicine is available in packages of 10, 25, 30, 40, 50 and 100 tablets.

The composition of the drug Nitroxoline includes the active substance nitroxoline in an amount of 50 milligrams.

Auxiliary components: lactose, magnesium stearate, colloidal silicon dioxide, titanium dioxide, magnesium carbonate, potato starch, corn starch, talc, granulated sugar, food gelatin, povidone-25, macrogol 6000, tropeolin O, red acid dye 2C.

Indications

Indications for use of the drug Nitroxoline:

infectious inflammatory diseases of the genitourinary tract (cystitis, urethritis, pyelonephritis, epidymitis);
infected prostate adenoma or carcinoma;
infectious diseases caused by bacteria and microbes described in the list;
prevention of infectious complications during diagnostic and therapeutic procedures (catheterization, cystoscopy);
prevention of infectious complications after surgical operations.

Contraindications

Contraindications to the use of the drug Nitroxoline:

chronic renal failure, in which the daily volume of urine is less than 500 milliliters;
chronic renal failure, which is accompanied by urinary retention (anuria);
severe liver disease;
deficiency of the enzyme glucose-6-phosphate dehydrogenase;
cataract;
neuritis of any nerve;
hypersensitivity to the components of the drug.

Nitroxoline is contraindicated during pregnancy, as well as during lactation.

In case of mild to moderate chronic renal failure, it is allowed to take the drug with caution and under the strict supervision of a physician.

If the patient has chronic renal failure, the daily dose of the drug should not exceed 800 mg, since the active substance nitroxoline accumulates in the blood due to the low rate of excretion by the kidneys, this can cause overdose symptoms and drug poisoning.

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Dosage and method of administration

Dosage for adults is 600-800 milligrams per day, the dose should be divided into 3-4 doses at intervals of 6-8 hours. The duration of the course of treatment is 10-14 days. The maximum daily dose is 1-1.2 grams.

Dosage for small patients is 10-30 milligrams per 1 kilogram of body weight per day, divided into 3-4 doses.

The duration of treatment for chronic recurrent diseases can be several months.

Side effects

When taking the drug Nitroxoline, the following side effects may develop:

From the gastrointestinal tract - attacks of nausea and vomiting, lack of appetite, in rare cases, liver dysfunction occurs.
From the central nervous system and peripheral nervous system - headaches, ataxia, polyneuropathy, paresthesia; with long-term use, optic nerve neuritis is possible.
From the cardiovascular system – tachycardia.
Allergic reactions - rash, itching.

Drug interactions

The combined use of Nitroxoline with tetracycline antibiotics such as Biomycin, Tetracycline, Doxycycline, etc., as well as with Nystatin or Levorin, provokes an increase in the effects of taking both medications. If combined use is necessary, you should consult your doctor to adjust the dosage of the drugs.

The antimicrobial drug Nitroxoline should not be used together with nitrofuran derivatives - Furacilin, Furagin, Furadonin, Furazolidone and others; taking these drugs together leads to increased side effects on the nervous system.

Antacids containing magnesium (Almagel, Maalox), when taken together with Nitroxoline, reduce its absorption and effectiveness. Nitroxoline reduces the absorption of nalidixic acid, therefore, if simultaneous use of both drugs is necessary, the dose of acid should be increased.

Price

The price of Nitroxoline varies from 70 to 100 rubles, depending on the pharmacy and the specific city.

Analogs

Nitroxoline - analogues of the drug:

Nitroxoline-UBF;
Nitroxoline-Acos;
5-NOK;
5-Nitrox.

For cystitis

The drug Nitroxoline - instructions for use for cystitis involves the use of 2 tablets 4 times a day, for 10-14 days, provided that the cystitis is acute and new. When taking the medicine, it is necessary to observe intervals of 6 hours; for convenience, tablets can be taken at 6.00, 12.00, 18.

00 and 24.00 hours. It is very important to continue the course of therapy even if the symptoms go away before completing the prescribed course; this will prevent the bacteria from developing immunity and prevent relapses. Treatment can be completed only after the results of three urine tests taken within three consecutive days are normal.

In the treatment of chronic cystitis, Nitroxoline is prescribed 2 tablets four times a day at regular intervals. If this dosage is not enough, then the doctor can increase it to 3-6 tablets at a time. The maximum daily dose is 20 tablets. The duration of the treatment course can be up to three weeks; after the end of therapy, the patient must undergo a control urine test.

You can leave your review about the drug Nitroxoline below!

Substitutes by principle of action

To treat inflammation of the bladder, other medications that act in a similar way are prescribed:

Furamag, furagin, furasol (based on nitrofuran). Prescribed when an acute form of the disease occurs. The main advantage is rare side effects. The minimum duration of use is 3 days. Reviews of people who have used nitroxoline for cystitis indicate that these drugs are well tolerated by patients, but are not recommended if there are diseases of the kidneys, respiratory system, or diabetes.
Monural, forfural (based on fosfomycin). They are used if inflammation of the bladder is associated with Escherichia coli, Proteus, Klebsiella. Effective in eliminating urogenital infections.
Penicillins. Quickly and effectively destroy bacterial pathogens. Prescribed by doctors in the field of urology if nitroxoline for cystitis does not give the desired result.
Fluoroquinols. They block the DNA gyrase enzyme, which leads to the death of pathogenic pathogens. During pregnancy and breastfeeding - prohibited.

How not to make a mistake with the diagnosis

Nitroxoline is an antibiotic. Therefore, if you notice changes in the outflow of urine, you should not immediately attribute everything to problems with the bladder. There are plenty of diseases in the body that give such a reaction. To be one hundred percent sure that the process of exacerbation in the bladder has begun, it is worth understanding a few facts. And only then try to identify the problem yourself.

Firstly, for inflammation to begin, pathogens must get inside. These include all types of fungi and bacteria:

influenza and ARVI;
sinusitis and tonsillitis;
furunculosis and E. coli;
Proteus and Staphylococcus.

"Nitroxoline"

Any sexually transmitted disease necessarily makes itself felt in the same way - inflammation of the bladder. As well as diseases that have arisen in neighboring organs and taking strong drugs for a long time. But the shell itself is dense, and bacteria are not able to penetrate just like that. To do this, certain moments must occur that will “spur” the appearance of infectious or non-infectious cystitis. It is enough to form kidney stones, damage the bladder with foreign objects, or simply endure the urge to go to the toilet. And within a few days, or even the next day, discomfort will arise in the area of the urethral canal, and then pain when urinating. At the same time, the smell of urine changes dramatically, as does its composition, color and consistency.

Symptoms of cystitis are:

pain and severe discomfort in the bladder area and during emptying;
desire to go to the toilet every quarter of an hour. But at the same time, the feeling of fullness remains;
urine becomes cloudy. Sometimes when the injury is severe, blood appears.

With cystitis, the urine becomes cloudy

It is rare that a patient experiences a decrease in appetite. Instead, vomiting and nausea occur. It cannot be said that the inflammatory process is accompanied by elevated temperature. Since the occurrence of such a symptom can occur in the case of a severe weakening of the immune system and damage to two or three nearby organs. Provided that a woman regularly freezes, then in any case diseases of the appendages will arise. This may be a standard inflammation, but also the formation of a cyst on one of the appendages.

Nitroxoline price, where to buy

The price of Nitroxoline in tablets is approximately 60 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Nitroxoline tablets p.o 50 mg No. 50 Anzhero-Sudzhensky HFZOOO Anzhero-Sudzhensky HFZ
Nitroxoline tablets p.o 50 mg No. 50 IrbitskyOJSC Irbitsky Chemical Plant

Pharmacy Dialogue

Nitroxoline (50 mg tablet No. 50)
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Nitroxoline 50 mg n50 tabletTathimpharmaceuticals OJSC
Nitroxoline avexima 50 mg No. 50 tabLLC "Avexima Siberia"

Pharmacy24

Nitroxoline 0.05g N50 tablets PAT “Vitamin” Ukraine
Nitroxoline 0.05g No. 50 tablets PAT NVC “Borshchagivsky chemical-pharmaceutical plant”, Kiev, Ukraine

PaniPharmacy

Nitroxoline coated tablets 0.05g No. 50 Ukraine , Vitamins
NITROXOLINE tablets Nitroxoline tablets. 0.05g No. 50 Ukraine, Tekhnolog ChAO

BIOSPHERE

Nitroxoline 50 mg No. 50 tablet p.o. Tekhnolog ChAO (Ukraine)
Nitroxoline 50 mg No. 50 tablet p.o. Irbit chemical plant (Russia)

Indications

It is recommended to take the drug mainly for infectious and inflammatory diseases of the urinary system caused by microorganisms sensitive to the drug:

cystitis; urethritis;

Nitroxoline is also used for pyelonephritis

pyelonephritis; epididymitis; prostatitis; adenoma and carcinoma of the prostate gland.

Tablets are also prescribed to prevent infectious complications after diagnostic procedures, urological or gynecological surgical interventions.

Opinion of specialists and patients

Almost all reviews about taking the drug Nitroxoline are positive. All of them can be divided according to the diseases for which they were prescribed.

For prostatitis

An excellent remedy for prostatitis. When problems with urination began, I thought that a pebble just moved, since something similar had already happened. But everything turned out to be much worse, since, unknown to me, I became infected with infectious prostatitis. They prescribed me Niroxalin, I was pleasantly surprised at the price, although I thought that I would probably have to take something more expensive. But I decided to drink for a week anyway. And I was right. Within a week, the pain in the groin area began to go away and it became easier to urinate, and after three, the pain completely subsided.

Alexander

Hurray, I finally found a remedy that helped me overcome my chronic prostatitis. I have been suffering from this disease for 10 years now, and during this time none of the antibiotics helped. The doctor advised me to try a long-proven remedy. At first it didn’t help, so I went to the doctor again and found out if this was normal. The doctor reassured me that I needed to drink it for at least a week to feel the difference. To my joy, the doctor was right and after 2 weeks the symptoms went away, and I haven’t seen a urologist for 4 years.

Gennady

For pyelonephritis

A few months ago my back began to hurt in the area of my kidneys. Well, I thought I pulled it and didn’t pay attention. And a day later the temperature rose to 39 degrees. I quickly ran to the doctor. After passing urine and blood tests, they sent me for an ultrasound of the kidneys, where they diagnosed pyelonephritis of the right kidney. The doctor prescribed Nitroxoline and bed rest.

The first couple of days I didn’t feel anything, but on the third day it started to go away and after a week all the pain and fever disappeared. And then, I made the mistake of thinking that the disease had subsided and stopped taking the medicine. And two days later I found myself at the doctor again with the same diagnoses. The doctor “scold” me and prescribed Nitroxoline again and strictly ordered me to drink it for three weeks. After the full course, everything returned to normal and so far the disease has not returned.

Basil

Miracle drug. I had food poisoning about a month ago. Well, I suffered for a day, the second, but the vomiting and fever did not go away and some pain appeared in the area of the kidneys. Well, I went to the therapist, took some tests and went home. The next day I come and they tell me that I have E. coli. And I say, why do my kidneys hurt? They sent me for an ultrasound, and it showed bilateral pyelonephritis. They prescribed this drug and sent me home.

I've been taking pills for a day, the second day, but I'm not getting any better. Well, I think that’s it, I ran away. I called a doctor I know, maybe he could recommend another medicine for a consultation. But he replied to continue drinking this one, you just need to wait a little. Well, if my friend already told me, then there is nothing to do, I continue to drink. And in fact, after three days, I finally began to return to normal, and after two weeks I forgot how bad I was.

Catherine

For cystitis

A normal drug that wins at the same price. I used it for cystitis, which I got by accident. The doctor prescribed it, saying that the product was good and would definitely help, but when I went to the pharmacy I doubted it because it was cheap. But there was only a recipe, so there was no choice. After 5 days, the symptoms began to gradually disappear and by the end of the 2nd week they had completely disappeared. But she finished the medicine to the end. The cystitis never returned.

Elena

Nitroxoline was prescribed for cystitis. After drinking it for three weeks, I feel great. There are no problems with urination. I was also struck by the low price and the fact that it turns out that this is not an antibiotic and the body cannot get used to it. I'm completely satisfied with the result

Svetlana

I have been working as a urologist for about 10 years. From the very beginning of my medical practice, I have prescribed Nitroxoline to patients suffering from cystitis. I consider this drug to be one of the best in terms of price-quality ratio. And over these 10 years, not a single patient has changed this antifungal drug to another

Peter

Indications and contraindications

This remedy is recommended for use in the following pathologies of the genitourinary system:

pyelonephritis; urethritis; epididymitis; infection of prostate adenoma or carcinoma.

Nitroxoline is most often taken for cystitis. But even if you have this disease, you cannot resort to using medication if the following diseases develop in parallel:

cataract; various neuritis; severe liver pathologies; individual intolerance to the components of the composition.

The drug is also not recommended for use during pregnancy and breastfeeding. The exception is cases in which the benefit to the mother outweighs the potential risk to the fetus. In case of renal pathologies, taking the drug is possible, but only on the recommendation of a doctor and with constant monitoring of changes in blood composition.

If the patient has contraindications, as well as if the dosage and duration of treatment are not observed, the following side effects may occur:

gastrointestinal disorders; allergic reactions; heart rhythm disturbances (arrhythmia, tachycardia); paresthesia; headaches.

If the dosage is exceeded, it is recommended to rinse the stomach, take absorbents and drink as much liquid as possible. If these measures do not help, you must call an ambulance. This should be done as quickly as possible so as not to worsen the patient’s condition.

Contraindications

Tablets should not be used for:

Functional disorders of the kidneys, accompanied by oliguria (slow urine production), anuria (no urine enters the bladder). Severe liver diseases. Cataracts. Neurites. Individual intolerance or hypersensitivity to the main/auxiliary components of the product.

The presence of cataracts is a reason to discontinue the drug

Pregnant and lactating women should not take the drug.

General information about the drug

Nitroxoline is a drug with an antimicrobial effect that effectively fights harmful microorganisms of diverse origin. This drug has a wide range of applications, so it is suitable for the treatment of almost all infectious diseases of the digestive, urinary, circulatory systems, lungs, central nervous system and other organs.

The main advantage of Nitroxoline over other common antimicrobial agents is its difference in structure from antibiotics and, as a result, its use does not cause antibiotic resistance in microorganisms, that is, bacteria cannot develop a resistant stamp to it.

The main active substance of the drug is nitroxoline. This material is synthesized on the basis of quinilones in a non-fluorinated way, so the drug is classified as a synthetic drug.

How it works, indications, contraindications

The product works by blocking the connection of nucleic acids of microbial cells. This is possible due to the fact that nitroxoline forms compounds with those microbial enzymes that contain metal: they provide the process of nuclein synthesis. If deoxyribonucleic acid is blocked, the parasites can no longer reproduce. The microbial cell continues to live, but does not reproduce, which means the population of microbes ends. Since the structure of the enzymes that ensure DNA replication in the microbes themselves and in human cells is different, the drug acts selectively and destroys exclusively microorganisms that carry diseases, but does not have a negative effect on our tissues and organs. The drug copes well with gram-positive bacteria:

Staphylococci (eg aureus);
Streptococci (hemolytic, faecalis)
All kinds of bacilli;
Corynebacterium spp.

It also affects gram-negative microbes, including Klebisella, Shigella, Salmonella, Proteus spp., Enetrobacteria, Escherichia coli. It also destroys gonorrhea pathogens and microorganisms such as mycobacterium tuberculosis and Trichomonas vaginalis. It has a detrimental effect on some types of fungi, for example, dermatophytes, mold, candida and other pathogens of mycoses). So nitroxoline is effective for cystitis and many other ailments. It is actively used for the treatment of pyelonephritis, epididymitis, urethritis, as well as for the prevention of infectious diseases during catheterization, operations on the genitourinary tract and kidneys, and cystoscopy). It can also be used for inflammation in the prostate tumor (caused by carcinoma or adenoma).

What else is important to know

While taking the pills, your urine may turn a bright yellow-orange color. This is a normal reaction that is absolutely safe for health. Goes away immediately after discontinuation of the drug. In patients with mild renal failure, the active ingredient may accumulate in the body. They can use the tablets, but with caution, under the supervision of the attending physician and with periodic monitoring of the composition of the peripheral blood. When taken simultaneously with antibiotics of the tetracycline group (Doxycycline, Tetracycline), Nystatin, Levorin, the therapeutic effect of all drugs increases, which requires dose adjustment. You cannot combine Nitroxoline with nitrofuran drugs (Furazolidone, Furagin, Furadonin), since the toxic effect of the drugs on the nervous system increases. In combination with antacids, the effectiveness of Nitroxoline is reduced.

Nitroxoline should be taken with caution when combined with other drugs.

About the product

Nitroxoline is sold under the name 5-nok and belongs to the antimicrobial agents from the hydroxyquinoline group. This also includes the previously popular enteroseptol, mexaform and intestopan. Hydroxyquinolines have not been used in the USA and European countries for a long time, but in our latitudes 5-noc for cystitis in women (men too) is prescribed quite often.

Before taking nitroxoline for cystitis, it is worth clarifying only one thing: whether it is an antibiotic. In fact, doctors believe that hydroxyquinolones are not antibiotics at all and they are antimicrobial agents with serious side effects. Like all similar medications, nitroxoline tablets for cystitis should be taken with extreme caution and according to the rules.