Amoxiclav for pyelonephritis: effectiveness and how to use correctly

The principle of action of the drug

Being an antimicrobial medicine, it allows you to neutralize the root cause of infectious and inflammatory diseases - pathogenic bacteria .

The use of such agents is required, including for infections localized in other organs and tissues, because many pathogens are sensitive to it. Accordingly, Amoxiclav eliminates the main cause of this dangerous disease.

It has repeatedly shown excellent results in the treatment of pyelonephritis of varying severity, which was confirmed in numerous clinical studies.

The combination of amoxicillin and clavulanic acid helps prevent the development of tolerance in pathogens, which is especially important given the duration of antimicrobial therapy for pyelonephritis.

It has been experimentally confirmed that this particular tandem increases the likelihood of complete recovery by 2 times, if we draw an analogy with medications that contain only amoxicillin. The explanation is simple: the acid prevents the destructive effects of enzymes secreted by bacteria on antimicrobial drugs.

Reviews on Amoxiclav for cystitis

Reviews of Amoxiclav for cystitis are mostly positive if the drug was prescribed by a doctor and taken as prescribed:

I was tormented by cystitis during pregnancy and did not give me peace for a long time. She examined the entire body: kidneys, bladder, donated a tank. crops - they found Staphylococcus aureus. The doctor prescribed Canephron to calm the symptoms and Amoxiclav to eliminate the pathogen. Thank God that this drug is allowed to be taken during pregnancy if everything is fine with pregnancy. After taking it I felt noticeably better, I took all the smears again - nothing was found. Alla, Moscow.
A month ago I took a course of Amoxiclav for cystitis, I have chronic cystitis, it constantly comes out whenever I catch a cold. Previously, I treated her with herbs and herbal preparations, I was so tormented that I decided to take a course of antibiotics. On the third day of treatment, I no longer had any signs of pain, I took the full week’s course just to be sure. Veronica, St. Petersburg.
My best friend is Amoxicillin for cystitis, I always choose drugs with it. When an attack occurs, I take an antibiotic for a course of 5-7 days, depending on the condition. It helps for a long time until I get an infection again. The main thing is to start taking a prebiotic along with taking Amoxiclav, then there will be no side effects. Irina, Kyiv.
My wife was prescribed Amoxiclav several months ago; she was still breastfeeding the baby, but they were about to wean her. It helped well at first, she took the full course, as the doctor recommended, it was accompanied by wild side effects, diarrhea tormented both my wife and child, and 3 weeks after taking it, cystitis returned again, after all, the best for cystitis are Zinnat and Amoxiclav - they don’t help forever, but for a long time. Victor, Minsk.
I ordered Amoxiclav from an online pharmacy and bought a package for 400 rubles. for 12 tablets. According to the instructions, you had to take 1 tablet, twice a day - I did that, after 3 days of taking it, the discomfort, fever and abdominal pain began to disappear, but severe diarrhea and headache began. I recommend it as an ambulance for severe cystitis with fever; in other cases you can do without antibiotics. Maria, Novosibirsk.
It’s a good remedy, a really effective remedy, the doctor prescribed Amoxiclav to me, I took the course and it became much easier. But there are other, no less effective herbal preparations that also fight pathogens and do not cause such harm to the microflora as an antibiotic. Vera, Nizhny Novgorod.

How to use it

Treatment tactics are determined by the following criteria: body weight, age, form of the disease, and severity of the patient.

The manufacturer provides the following dosage forms:

Injection powder for preparing a solution.
Tablets for internal use.
Suspension.

In the acute course of the disease, at the beginning of therapy, a course of Amoxiclav injections is given (1.2 g 3 times a day until the condition improves, usually about 5 days), then the patient is transferred to tablets or suspensions.

In this case, the duration of treatment is about two weeks; in case of relapses, preventive treatment is required for six months, but if necessary, the course of treatment can be extended to a year. The dosage is selected individually .

Generally speaking:

In children under 3 months (from 2 kg) - use a suspension with a minimum content of active ingredients,
Suspension 250/62.5 mg and 400/57 mg is used from 3 months of age,
Tablets are indicated from 12 years of age (from 40 kg), as well as for adults. Daily dose 2-3 tablets.

There are 3 tablet dosage options: 250/125 mg, 500/125 mg and 875/125 mg. The doctor gives instructions on the required dose for a particular patient.

Amoxiclav for cystitis in women

Treatment of cystitis in women in most cases is ineffective, and the disease almost always recurs. Amoxiclav for cystitis has long established itself as an effective and quick remedy. The effect of the drug on the body and pathogenic organisms has been well studied, the drug is the least toxic, due to which side effects rarely occur.

Amoxiclav tablets for cystitis are an antibacterial drug, combined action, of the penicillin group. The drug successfully fights a large number of pathogenic microorganisms that are the causative agents of most genitourinary infectious diseases. Not all antibiotics for cystitis are equally effective. Only Amoxiclav contains clavulanic acid, which not only destroys bacteria, but also prevents their further reproduction.

The course and dosage of Amoxiclav for cystitis is prescribed by the attending physician and must be strictly followed. This drug is prescribed in complex therapy of the disease, since it eliminates the cause of the infection, and not its symptoms.

The active ingredient of the drug Amoxicillin for cystitis reaches its concentration in the body a couple of hours after administration, and then the effectiveness begins to decrease, and the drug is excreted from the body. Due to the rapid elimination, you can drink Amoxiclav for cystitis during breastfeeding immediately after the next feeding of the baby.

In addition to female cystitis, this antibiotic has the following indications:

acute male cystitis;
infectious diseases of the respiratory tract, middle ear;
pyelonephritis;
infections of the reproductive system;
bone diseases.

The drug is also used to treat many diseases in children.

How to combine with other medications

Because Amoxiclav is a serious medication; it is better to take it separately from the rest to avoid interactions between the active substances.

Cannot be combined with courses of the following medications:

Blood thinners - to avoid too much reduction in blood clotting.
Teturami its analogues - increases mutual toxicity.
Other antimicrobial agents may weaken the effect of Amoxiclav.
Contraceptives (their effectiveness is weakened).

Therefore, it is important to inform the attending physician about concomitant diseases and treatments that are already being carried out.

Contraindications

It is advisable to use Amoxiclav to treat infections caused by sensitive microorganisms:

urinary tract (with pyelonephritis and urethritis);
gynecological diseases;
lesions of the skin and soft tissues;
bites of humans and animals;
upper and lower respiratory tract (bronchitis, sinusitis, tonsillitis, pneumonia, chronic otitis media, pharyngitis);
biliary tract;
connective tissue and bones.

Intravenous administration of Amoxiclav solution is indicated for therapy:

abdominal infections;
infections transmitted during unprotected sex;
to prevent infection after surgery.

We suggest you familiarize yourself with Corns with a rod on the sole, treatment

Is this treatment method safe?

Amoxiclav is a low-toxic drug, however, a number of negative aspects may occur.

The most common are:

Dysbacteriosis.
Rashes, itching and other manifestations of allergic reactions.
Discomfortable sensations in the stomach and intestines.
Headache, dizziness.
Deterioration of indicators in analyses.

These manifestations can be minimized using simple rules:

Take after meals with water (1/2 cup),
It is advisable to combine it with probiotics, which will protect the intestinal microflora from its destructive effects.

Why you should pay attention to the drug

The use of Amoxiclav has a number of advantages over drugs with similar effects:

Available in several forms, which allows you to choose the one that is more suitable for the body;
the medicine is sold at an affordable price;
has high and stable bioavailability (more than 50%);
can be consumed both before and after meals;
amoxiclav not only has a bactericidal effect, but also has a bacteriostatic effect. Thanks to this, not only pathogenic microorganisms are eliminated, but their reproduction is also stopped.

How can I replace Amoxiclav?

Generics (substitutes) are: Arlet, Ecoclave, Augmentin, Panclave, Flemoxin Solutab, Rapiclav, etc., produced by foreign and domestic pharmaceutical companies.

Doses of clavulanic acid may vary from manufacturer to manufacturer.

Do not chase a low price, because a low cost means that such a medicine has not undergone clinical studies that would prove its effectiveness in treating this disease.

Remember ! Antibiotics containing only amoxicillin are not analogues of Amoxiclav.

Side effects and overdose

Treatment with Amoxiclav may be accompanied by unwanted side reactions from various body systems.

the digestive system often reacts with the following manifestations: pain in the epigastric region, impaired liver function, hepatitis, loss of appetite, gastritis, stomatitis, darkening of tooth enamel, stomatitis, cholestatic jaundice, hemorrhagic colitis, glossitis. In older people (usually males), long-term therapy may result in liver failure.
from the central nervous system, convulsions, dizziness, insomnia, anxiety, and headaches may occur. Most often, such manifestations are observed in people with impaired renal function.
from the urinary system, hematuria, inflammation of the interstitial tissue and renal tubules, crystalluria are observed;
allergic reactions manifest themselves in the form of urticaria, itching, angioedema, anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic vasculitis, exudative erythema multiforme.

Like any other antibiotic, Amoxiclav should not be mixed with drinks containing alcohol.

Strong drinks can minimize the therapeutic effect of the drug, but this outcome is not the worst. Mixing with amoxicillin and clavulanic acid, alcohol increases the risk of unwanted side effects several times.

The load on the liver and kidneys increases, which are forced to get rid of not only the breakdown products of the drug, but also the remnants of alcohol. It is recommended to postpone the consumption of alcoholic beverages until the end of the full treatment course.

Analogs

If the use of the drug is impossible for any reason, it should be replaced with a drug that has a similar effect. Currently, there are no complete analogues of Amoxiclav.

There are several medicines with a similar composition that are used in the treatment of cystitis, these include:

Panclave;
Flemoklav Solutab;
Clamostar;
Arlet;
Augmentin;
Bactoclav;
Clavicillin.

Some analogues are no less effective and cost much less.

Features of the drug

Amoxiclav is an antibacterial agent belonging to the penicillin group.
Amoxiclav is an antibacterial agent belonging to the penicillin group. This is a new generation antibiotic that has a broad spectrum of action and is a type of penicillin of semi-synthetic origin. Amoxiclav is very often used to treat cystitis and other inflammatory pathologies of the urinary system, as well as in gynecology.

Amoxiclav for kidney problems has a number of advantages compared to other antibiotics of similar action:

the medicine has several release forms, which allows you to choose the type that is suitable for each patient; the drug has a very reasonable price; the drug has stable high bioavailability, which is more than 50%; the drug can be taken regardless of meals; In addition to the bactericidal effect, Amoxiclav has a bacteriostatic effect, that is, the active substance not only destroys microbes, but also prevents their reproduction.

Release forms

Various forms of medication can be used to treat various kidney ailments and pathologies of the urinary system.
The following forms of medication can be used to treat various kidney ailments and pathologies of the urinary system:

tablets in a dosage of 0.25; 0.5 and 0.875 g; for the treatment of children, powder is used from which a suspension is prepared (5 ml of suspension may contain 0.25 or 0.4 g of active substance); bottles with soluble powder for intravenous use (medicine dosage - 500, 1000 mg).

In any form of the drug there are two active substances:

amoxicillin is an antibacterial agent of the penicillin group; Clavulanic acid is a substance that prevents bacteria from developing resistance to amoxicillin and thereby helps destroy pathogenic microorganisms.

Reviews

For a long time I suffered from chronic cystitis. Exacerbations occurred several times a year. I tried several drugs. At the last appointment, the attending physician recommended treating the disease with Amoxiclav. The medicine really helps, no side effects were observed, the course of administration is very convenient. I recommend everyone to pay attention to this medicine.
Maria, 38 years old (Chelyabinsk)

At the first signs of cystitis, I start taking Amoxiclav, the pain and discomfort go away very quickly. The drug is very effective. A minor side effect was expressed in the form of abdominal upset.
Natalia, 30 years old (Khabarovsk)

I take the medicine as prescribed by the doctor. The unpleasant symptoms disappeared after a five-day course. To avoid side effects, you should strictly adhere to the treatment regimen.
Anna, 35 years old (Kazan)

Release forms

In any form of the drug there are two active substances:

A little history

The creation of amoxiclav dates back to the late 70s of the last century, when it was discovered that clavulanic acid has a powerful inhibitory effect. Since the beginning of the 80s, the pharmaceutical company Sandoz in Slovenia managed to develop its own acid synthesis, and by the end of the 90s, the combination drug amoxiclav based on the amoxicillin tandem, protected by an inhibitory component, appeared on our pharmaceutical markets.

Powder for cystitis: list of drugs, their purpose and properties

Treatment and dosage

The dosage of the drug and the duration of treatment are determined by the doctor individually, taking into account the nature of the disease.
The dosage of the drug and the duration of treatment are determined by the doctor individually, taking into account the nature of the disease and the individual characteristics of the patient.

Important: before prescribing treatment, you need to take a CBC and FAM to confirm the presence of an infectious-inflammatory process. The doctor may also prescribe a bacterial culture of urine, which will identify the causative agent of the disease and assess its sensitivity to antibiotics of different groups.

Typically, the duration of antibiotic therapy is 5-14 days. For mild to moderate severity of the disease, a tablet form with a dosage of 250 mg is prescribed, which should be taken one piece every eight hours. To treat severe forms of the disease, tablets are used in a dosage of 500 mg, which are taken every 12 hours.

The doctor determines the dosage of the medicine taking into account:

the patient's age and weight; general condition of the body (the presence of chronic diseases is taken into account); stage of development of the disease and the severity of its course; functioning of the kidneys and liver (presence of renal and/or liver failure).

The duration of treatment for cystitis with Amoxiclav is three days. Therapy for pyelonephritis lasts at least seven days, and a two-week course is indicated for the treatment of urethritis.

When should you not take medicine?

Amoxiclav 875 125 should not be prescribed to the following categories of people:

Persons with hypersensitivity to the drug. According to the instructions, the use of Amoxiclav is prohibited for persons with increased sensitivity to its composition. Especially if the medicine was taken in concentrations of the active compound of more than 125 mg. These suspensions are also contraindicated for children. Therefore, patients with cystitis are treated with the use of Amoxiclav analogues.
For babies whose weight is less than forty kg. Amoxiclav 2x cannot be used in the treatment of a child if his weight is less than forty kilograms and his age has not exceeded twelve years. 125 mg of the active compound that Amoxiclav contains is dangerous for a developing child's body. It is advisable to give the suspension to adolescents with appropriate body weight.
People suffering from liver diseases. Amoxiclav contains many compounds that negatively affect the functioning of the digestive organs in people with cholestatic jaundice. Therefore, when treating adults, a detailed examination of the body is first carried out and only then the drug is prescribed.

Amoxiclav is recommended to be used with great caution during pregnancy. Each of its tablets contains substances that can negatively affect the condition of the fetus developing inside the mother. Therefore, the instructions prohibit the free use of this medicine. Amoxiclav during breastfeeding is prescribed by a doctor only in extreme cases.

The scope of application of this drug allows the use of Amoxiclav during pregnancy only when the benefits of such use are much greater than the harm it causes. Among the variety of medications, there are many analogues of the drug that are prescribed to ladies “in an interesting situation.” Amoxiclav during pregnancy can negatively affect many systems of the baby, so ladies should remember this and not take risks in case of self-medication.

Among the variety of tablets for cystitis, the scope of which is very wide, Amoxiclav occupies one of the leading positions. Only before using it is it recommended to read the instructions and visit the appropriate doctor, only then will there be no harm to your health. This medicine should be used in accordance with the expiration dates indicated on the package.

What is cystitis and its features

Cystitis is the most common disease of the genitourinary system, characterized by an inflammatory process that occurs in the bladder. Microorganisms enter the organ, infect it and become the cause for the development of the disease. Pathology can be either acute or chronic. Most often it develops for the following reasons:

Sexual and intestinal infections
Failure to comply with personal hygiene rules
Stagnation of urine
Hypothermia and poor nutrition
Instrumental interventions in the organ
Metabolic disorders
Women are going through menopause.

Symptoms of the disease are mainly pronounced - pain in the lower abdomen, frequent trips to the toilet, burning and pain when urinating; in severe cases, the temperature may rise, and blood may appear in the urine. Read more about blood in urine in the article: blood in urine with cystitis. In any case, the disease requires treatment, which can be effectively carried out with the help of special medications.

Treatment and dosage

Important: before prescribing treatment, you need to take a CBC and FAM to confirm the presence of an infectious-inflammatory process. The doctor may also prescribe a bacterial culture of urine, which will identify the causative agent of the disease and assess its sensitivity to antibiotics of different groups.

The doctor determines the dosage of the medicine taking into account:

The duration of treatment for cystitis with Amoxiclav is three days. Therapy for pyelonephritis lasts at least seven days, and a two-week course is indicated for the treatment of urethritis.

Indications for use

In addition to cystitis, this medication can be used in the treatment of other pathologies of a bacterial nature:

inflammation of ENT organs;
pneumonia, bronchitis;
gynecological infectious diseases;
inflammatory dental processes;
skin infections;
recovery after surgery;
abscess;
infection of joints and bone tissue, etc.

The drug "Amoxiclav" can be used strictly according to clinical indications. Uncontrolled use of this drug entails the development of adverse reactions, and an arbitrary increase in dosage can lead to intoxication. If nausea, dizziness, loss of consciousness or convulsions occur, seek help immediately.

Features of the drug

Amoxiclav for kidney problems has a number of advantages compared to other antibiotics of similar action:

What effects does Amoxiclav have?

"Amoxiclav" has a pronounced effect on the pathological process in the organ. The drug exhibits activity within 2-3 hours from the moment of administration, since during this time the maximum concentration of the substance in the plasma is reached.

The following effects are formed:

Within 2-3 days the intensity of the pain syndrome decreases.
There is an improvement in the process of urination.
Pathological components disappear from urine.
The condition is improving.

Due to the pronounced antibacterial activity, the inflammatory process gradually passes in the wall of the bladder.

Proliferation processes intensify, which leads to complete recovery. If you have cystitis, you need to take the drug according to the regimen determined by your doctor. If you miss taking pills, the effect is reduced.

Conducted antibacterial therapy must be constantly maintained by drug concentrations.

Failure to follow the doctor's recommendations leads to a marked decrease in bactericidal activity.

There is a risk of becoming chronic.

"Amoxiclav" for chronic cystitis is used only at the time of exacerbation. In the absence of severe symptoms, there is no need to take the drug.

An integrated approach to solving the problem

Cystitis is considered one of the most common diseases of the urinary system in women. Due to the short, wide urethra and the anatomical proximity of the perianal zone, E. coli and other microorganisms penetrate the mucous membrane and cause inflammation.

WHAT DO THE DOCTOR'S SAY?

Doctor of Medical Sciences, Honored Doctor of the Russian Federation and Honorary Member of the Russian Academy of Sciences, Anton Vasiliev:
“I have been treating diseases of the genitourinary system for many years. According to statistics from the Ministry of Health, cystitis in 60% of cases becomes chronic.

The main mistake is delaying!
The sooner you start treating cystitis, the better. There is a remedy that is recommended for self-treatment and prevention of cystitis at home, since many patients do not seek help due to lack of time or shame. This is Ureferon. It is the most versatile. It contains no synthetic components, its effect is mild, but noticeable after the first day of use. It relieves inflammation, strengthens the walls of the bladder, its mucous membrane, and restores general immunity. It is suitable for both women and men. For men there will also be a pleasant bonus - increased potency. » READ FULL INTERVIEW»
The following predisposing factors contribute to this:

disruption of the vaginal microflora due to improper use of tampons, vaginal lubricants, and hygiene products;
wearing tight synthetic underwear and tight trousers;
constant hypothermia, untimely treatment of inflammatory processes in the uterus and appendages;
alcohol consumption, an abundance of excessively spicy foods in the diet;
frequent abortions;
history of sexually transmitted diseases;
regular change of sexual partners.

To effectively treat cystitis, prescribing Amoxiclav or another antibiotic is not enough. What is important is an integrated approach, which requires the exclusion of the predisposing factors listed above. Only in this case can frequent relapses of cystitis and the occurrence of complications be avoided.

Properties of antibiotics

Amoxicillin and Amoxiclav belong to the category of new generation antibiotics. Both drugs have a wide spectrum of action. The general requirement for all modern antibiotics is high antibiotic properties, because the quality of treatment of diseases directly depends on them. An equally important point is minimal nephrotoxicity, the level of which affects the condition of the kidneys.

Amoxiclav

During cystitis and pyelonephritis, as well as other diseases of internal organs, it is important that antibiotics are removed as soon as possible. Amoxicillin and Amoxiclav have this property and are excreted from the body in high concentrations along with urine.

The main problem in treatment with antibiotic drugs is the gradual addiction to them. Despite the advertising assurances of pharmaceutical companies, the effectiveness of the antibiotic gradually decreases with long-term use. That is why the optimal interval between taking antibiotics is one year.

An important role in this process is played by the duration of the course of treatment and the dosage of the medicine prescribed by the doctor. Here, one of the tasks is to reduce the risk of developing nephrotoxicity, which can occur not only due to incompatibility of drugs or frequent use of antibiotics, but also due to age , so elderly people fall into the risk category.

The consequences of antibacterial therapy for children are no less dangerous than for adults. Incorrect selection of the dose of the drug or an insufficiently long course of treatment leads to dire consequences. Adults know very well: self-administration of antibiotics is unacceptable. But uncontrolled, frequent use of antibiotic drugs by children at home is the norm in a number of families.

The child’s body reacts more sharply to an irrational combination of antibiotics with each other, and disturbances in the functioning of internal organs turn out to be deeper, including malfunctions of the kidneys and a decrease in the body’s immune defense.

Pregnancy and children

The active components of the drug tend to pass into breast milk in small quantities. During breastfeeding, it is recommended to suspend treatment with Amoxiclav.

The use of a medication during pregnancy is possible if the expected benefit to the woman is higher than the potential harm to the child

Most often, Amoxiclav therapy is required for children with tonsillitis. The medication prevents the spread of streptococci that cause the disease. The maximum permissible daily dose is 45 mg per 1 kg of body weight. Young children are given the antibiotic to drink in the form of a suspension. An older child (up to 12 years old) is prescribed 40 mg per 1 kg of weight. If the child's weight is more than 40 kg, the daily dose is calculated as for an adult.

The dosage for children cannot be calculated independently. The permissible amount of antibiotic should be calculated by the doctor who prescribed the treatment.

Composition of the drug and its release options

The main component of the drug is amoxicillin. Amoxiclav also contains clavulanic acid. The product is available in two versions: tablets and powder. Tablets are sold in a standard dosage of 375 mg. The product is also available in doses of 625 and 1000 mg.

Dose in mg / number of tablets per package	Amoxicillin value in mg	Clavulanic acid content in mg
375/15	250	125
625/14-15	500	125
1000/14	875	125

The drug Amoxiclav in powder form is sold in dosages of 312.5 and 457, respectively. The product in powder form is intended for the preparation of a suspension that must be taken orally. The mixture must be mixed with water. The ratio must be observed: 250 mg of product and 85 ml of water.

How does lingonberry help with cystitis?

Amoxiclav is also available in the form of solutions used for intravenous injection. Solutions of the product are available for sale in dosages of 600 and 1200 mg. Amoxiclav in the form of an injection solution is available in bottles. One pack contains 5 bottles.