Veroshpiron is a potassium-sparing diuretic of synthetic origin, used in medical practice to establish water and electrolyte balance in the human body.
The main active, potent component of the drug is spironolactone. The tablets contain 25 mg of the active element, and the capsules contain 50 and 100 mg of the active substance.
The drug is often recommended in the complex treatment of arterial hypertension. In this regard, it is necessary to figure out how to take Veroshpiron? When can you take this product, and what do the instructions for use say?
Pharmacodynamics and pharmacokinetics
The main substance is spironaloctone . In the distal parts of the nephron, it prevents the retention of water and sodium by aldosterone, reduces the potassium-removing effect of aldosterone, and reduces the synthesis of permeases .
The maximum effect of taking the drug is observed 7 hours after taking the capsule and lasts for 24 hours. A decrease in blood pressure is achieved by a diuretic effect, which manifests itself after 2-5 weeks of use. The active substance becomes active metabolites. The medicine is excreted by the kidneys.
general information
Veroshpiron was created in the middle of the last century and is still very popular because, compared to other diuretics, it has a minimal effect on water and electrolyte balance.
Drug group
Veroshpiron is the trade name of a drug belonging to the pharmacological group of potassium-sparing diuretics. Throughout the world, this drug is known by its International Nonproprietary Name - Spironolactone.
Drugs created on the basis of spironolactone and produced under various trade names are actively used in almost all countries of the world to reduce blood pressure and relieve the patient of excess fluid in the body.
The drug is primarily used in medicine to lower blood pressure and eliminate edema in heart failure. Its use is also necessary for potassium deficiency caused by taking medications. It is especially popular among bodybuilders - professional athletes take the drug to lose weight before competitions and improve muscle definition.
Forms of release and cost
Veroshpiron can be found in any pharmacy and purchased at a very low price. The drug is available in two forms and three dosages, the average cost of which can be seen in the table (Table 1).
Table 1 - Cost
| Release form, dosage | average cost |
| Table, No. 20, 25 mg | 65 rub. |
| Table, No. 30, 50 mg | 150 rub. |
| Caps., No. 30, 100 mg | 220 rub. |
| Caps., No. 30, 50 mg | 170 rub. |
The drug under the trade name Verospiron is produced only by the Hungarian company GEDEON RICHTER. But other products with similar effects are produced based on spironolactone.
Compound
The active component of Veroshpiron, which affects the properties of the drug - spironolactone - is a substance that acts similarly to aldosterone, but leads to the opposite result.
Other components of the drug have an auxiliary effect. In addition to spironolactone, the tablets contain: magnesium stearate, colloidal silicon dioxide, milk sugar, talc and starch. Additional substances in the capsules are: sodium lauryl sulfate, magnesium stearate, starch and lactose monohydrate.
Pharmacodynamics and pharmacokinetics
The action of the drug is based on the competitive ability of spironolactone to bind to receptors in the nephrons, before aldosterone, which is one of the main hormones synthesized in the renal cortex. Its main function is to retain fluid and sodium ions in the human body.
Spironolactone has the opposite effect - it promotes the removal of fluid and sodium, but at the same time retains potassium and, to a lesser extent, magnesium and urea, increasing their content in the blood.
As a result of taking the medicine, diuresis improves, urine acidity and high blood pressure decrease, and the functioning of the cardiovascular system is normalized. The drug maintains electrolyte balance, which is especially important for patients with pathologies of the heart and kidneys.
Veroshpiron has a mild effect, and the diuretic effect appears on days 2-5 of taking the drug. But the hypotonic effect appears already on the first day after the start of treatment.
The drug is quickly and almost completely absorbed from the gastrointestinal tract, and the rate of absorption is higher if the medicine is taken simultaneously with meals. After a single dose, the maximum concentration of the active substance in plasma is achieved no later than 6 hours. If you take the drug daily for 15 days, the concentration of the drug will reach 80 ng/ml.
Mechanism of diuretic action of the drug
Spironolactone is metabolized in the liver and excreted in the urine, and only a small amount of metabolites is excreted through the intestines. One of the metabolites, carenone, is eliminated in two steps. The first half-life lasts about 3 hours, the second - from 12 to 96 hours. The half-life is increased in patients with heart failure and cirrhosis.
Is it a diuretic or not?
Veroshpiron is a diuretic drug, but its purpose is not only to remove excess fluid, but also to reduce high blood pressure. Therefore, the drug is mainly prescribed for hypertension, renal hypertension and heart disease accompanied by edema.
Indications for use of Veroshpiron
What is the medicine for? Let's look at why Veroshpiron is prescribed.
Tablets and capsules are used as part of combination therapy for essential hypertension . Indications for the use of Veroshpiron also include: edema syndrome in CHF, nephrotic syndrome, ascites, cirrhosis of the liver. The drug is also used as an auxiliary substance in the prevention of hypomagnesemia/hypokalemia during treatment with diuretics. The medicine is successfully used for Conn's syndrome during the preoperative short course of treatment, as well as for the purpose of establishing the diagnosis of “ Primary hyperaldosteronism ”.
Characteristics of Furosemide
A loop diuretic with a rapid effect allows you to achieve almost instantaneous action when administered intravenously, so it is indispensable as an emergency medicine. If we compare the principle of action of Furosemide with the previous drug, it becomes clear why accelerated urine excretion occurs. Prostitutes of Simferopol The active substance enhances filtration processes in the central sections and blocks reverse absorption, due to which the volume of excreted fluid increases several times.
Furosemide
Contraindications
Contraindications for Veroshpiron are: hypersensitivity to the components of the drug, hyperkalemia, hyponatremia, Addison's disease , anuria , severe renal failure (creatinine clearance less than 10 ml/min), pregnancy and lactation. The drug is prescribed with extreme caution for metabolic acidosis , hypercalcemia, AV blockade, diabetes mellitus, diabetic nephropathy, menstrual irregularities, general and local anesthesia, liver and kidney diseases, as well as in the elderly.
Doses of the drug
The dosage is selected by the doctor only on an individual basis; this will be affected by the severity of the disease, the age of the patient and many other factors. The general dosages of Furosemide are as follows:
- Adults are prescribed twenty to eighty milligrams per day, which can be taken at one time or several times.
- Injections are given in quantities from twenty to two hundred and forty milligrams. Sometimes the dosage may be increased.
- Children are prescribed one milligram per kilogram of the baby's weight. But no more than six milligrams per kilogram. Over time, this dose may be increased or decreased, depending on the tests.
Side effects
Gastrointestinal tract: diarrhea, nausea, vomiting, gastritis , constipation , intestinal colic, liver dysfunction.
Central nervous system: lethargy, ataxia, headaches, dizziness, lethargy, drowsiness, muscle spasms, confusion, calf muscle cramps.
Side effects from the hematopoietic organs: thrombocytopenia, agranulocytosis, megaloblastosis.
Metabolism: hypercreatininemia, hyperuricemia, hyperkalemia, increased urea levels, hyponatremia, hyperchloremic metabolic alkalosis and acidosis.
Endocrine system: men may develop gynecomastia, erectile dysfunction , and decreased potency. In women amenorrhea , dimenorrhea, hirsutism , terorrhagia, and breast carcinoma are possible.
Allergic reaction: itching, drug fever, urticaria, erythematous, maculopapular rash.
Dermatological reaction: hypertrichosis, alopecia .
Urinary system: acute renal failure.
Overdose
With an inappropriate increase in the individual daily norm, overdose symptoms may develop, which resemble adverse reactions, but have a pronounced character. Fortunately, such cases were recorded extremely rarely and manifested themselves as follows:
- There was a feeling of intense thirst, all mucous membranes completely lost moisture;
- The level of acidity in urine increased significantly;
- Attacks of nausea and vomiting were observed;
- Rashes appeared on the skin;
- The patient suffered from loose stools;
- Dehydration of the whole body developed.
To prevent unpleasant consequences after an overdose, the victim should immediately seek qualified help.
To eliminate these symptoms, doctors recommend drinking plenty of water and inducing the gag reflex yourself (stick two fingers down your throat). After cleansing your stomach, you should drink coffee to increase your blood pressure.
In more severe cases, doctors resort to administering dextrose and insulin or, even worse, performing hemodialysis.
Instructions for use of Veroshpiron (Method and dosage)
The instructions for use for Veroshpiron capsules and tablets are the same. It all depends on the amount of active substance taken.
Essential hypertension: Adults: 50-100 mg once. The dose can be gradually increased to 200 mg, the amount of the drug is increased once every 2 weeks.
Idiopathic hyperaldosteronism: 100-400 mg per day.
Severe hyperaldosteronism, hypokalemia: 300 mg per day in 2-3 doses. Gradually, the dose of the drug is reduced to 25 mg per day.
Hypomagnesemia, nipokalemia, provoked by the action of diuretics: 25-100 mg per day, once or in several doses.
Diagnosis and treatment of primary hyperaldosteronism: 400 mg per day for 4 days. The daily dose of the medicine is divided into several doses.
How to take for swelling?
Edema in nephrotic syndrome: adults 100-200 mg per day. Veroshpiron is used only if other treatment methods have been ineffective.
Edema syndrome in CHF: 100-200 mg per day (several doses) for 5 days in combination with thiazide and loop diuretics. The daily dose can be reduced to 25 mg.
Edema in cirrhosis: if the Na+/K+ ratio in the urine is above 1.0, then 100 mg is prescribed. If less than 1.0, then the daily dose is 200-400 mg.
Edema in children: initially 1-3.3 mg per 1 kg of body weight, or 30-90 mg/m2 per day for 1-4 doses. After 5 days, the dose is adjusted.
How long can I take it?
The usual course is 20 days, followed by a break of at least six months. The longest possible use is for a couple of months. Long-term use can lead to acute renal failure.
Should I take it before or after meals?
It is recommended to take the medicine after meals.
Features of the use of diuretics for various diseases
Diuretics can reduce the volume of fluid in the abdominal cavity and reduce pressure in it, but each medicine has its own characteristics. When prescribing, it is important to take into account the patient’s condition and associated problems.
With cirrhosis, the liver does not filter the required volumes of blood. Because of this, ultrafiltrate accumulates in the abdominal cavity. It is liquid and easily seeps through the vascular walls. Half of the patients die, and diuretics for liver cirrhosis with ascites help prevent death. They are prescribed for controlled fluid removal.
Veroshpiron is often used, although in cases of severe dropsy it is insufficiently effective. The drug begins to act only on the third day, and with rapidly progressing ascites, every minute counts.
Therefore, Veroshpiron is prescribed together with Furosemide, Bumetanide or other loop diuretics. During pregnancy and breastfeeding, Veroshpiron is contraindicated, so only loop diuretics are used.
Spironolactone and Furosemide are used to treat dropsy due to cancer. Lasix and Diacarb are also prescribed. Taking diuretics is recommended, even if there is no pronounced effect.
With dropsy due to heart failure, the legs often swell. Diuretics relieve stress on the heart and help reduce pressure in the abdominal cavity. As a result, swelling decreases.
For mild heart failure, thiazide diuretics are effective, including Indapamide, Hydrochlorothiazide, Chlorthalidone. When blood circulation becomes difficult, loop diuretics are needed - Furosemide, Torasemide, Diuver.
Diuretics with herbal composition have a gentler effect on the kidneys, which is why they are preferable for kidney problems. You can use drugs like Canephron and Nephropil, decoctions and tinctures of chamomile, milk thistle, and nettle. Correctly selected collection increases the volume of urine excreted by 25 times.
If ascites has developed against the background of kidney inflammation, Furosmid is prescribed once a day - in this case the function of sodium excretion does not deteriorate. The effect occurs within half an hour and lasts up to 8 hours. In case of renal failure, the drug is effective even with a significant decrease in the filtration rate.
Prescribing Furosemide to a pregnant woman is allowed when there is a threat to the woman’s life. It crosses the placenta, so strict medical supervision is required. When breastfeeding, the medicine is discontinued, since it passes into the mother's milk and impairs lactation.
The simplest classification of diuretics contains a division by origin:
- Natural diuretics of plant origin have a mild effect and are used in folk medicine to gradually reduce edema of various origins.
- Pharmacological drugs begin to work faster and are often first aid when it is necessary to eliminate the dangerous symptoms of fluid retention in the body.
All synthetic drugs with diuretic properties are divided into several groups:
- Thiazide. They reduce the processes of reverse absorption and remove microelements that retain water from the body. They have an average speed of action.
- Osmotic. They change the ratio of pressure in the bloodstream and tissues. Long-term use is required to achieve the effect.
- Loopbacks. They accelerate the filtration processes in the central system of the renal tubules and at the same time slow down the reabsorption of water in the distal sections, thereby increasing the volume of urine produced. They act quickly and are classified as first aid.
- Potassium-sparing. They lower systolic pressure and retain potassium in the body due to hormonal regulation of diuresis. The speed of action is similar to loop diuretics.
Furosemide and Veroshpiron, respectively, belong to the last two groups of diuretic drugs and are more often found in doctor’s prescriptions when it is necessary to regulate urinary processes.
- Natural diuretics of plant origin have a mild effect and are used in folk medicine to gradually reduce edema of various origins.
- Pharmacological drugs begin to work faster and are often first aid when it is necessary to eliminate the dangerous symptoms of fluid retention in the body.
- Thiazide. They reduce the processes of reverse absorption and remove microelements that retain water from the body. They have an average speed of action.
- Osmotic. They change the ratio of pressure in the bloodstream and tissues. Long-term use is required to achieve the effect.
- Loopbacks. They accelerate the filtration processes in the central system of the renal tubules and at the same time slow down the reabsorption of water in the distal sections, thereby increasing the volume of urine produced. They act quickly and are classified as first aid.
- Potassium-sparing. They lower systolic pressure and retain potassium in the body due to hormonal regulation of diuresis. The speed of action is similar to loop diuretics.
Furosemide and Veroshpiron, respectively, belong to the last two groups of diuretic drugs and are more often found in doctor’s prescriptions when it is necessary to regulate urinary processes.
In the treatment of hypertension (abbreviated as hypertension), 2 properties of diuretics are important:
- Strength of action (weak, moderate and strong), which allows you to predict how long the medicine will take effect and remove the maximum amount of fluid.
- The duration of action allows you to determine the dosage and frequency of taking the tablets.
The pharmaceutical industry produces several groups of diuretics, which differ from each other in their mechanism (affect reabsorption in different parts of the renal tubule), strength and duration of action.
Commonly prescribed diuretic tablets for high blood pressure:
- Furosemide (Lasix), torsemide, bumetanide, uregit are powerful, fast-acting agents that begin to remove fluid within a few minutes (20 to 30) after administration. The duration of action expires quite quickly (after 2–8 hours), so they are often used as an emergency remedy in case of a sharp rise in pressure in order to prevent the development of a hypertensive crisis (damage to any target organ - the brain, retina, kidneys).
- Chlorthiazide, indapamide, hypothiazide - begin to work 1 or 2 hours after taking the tablet, the duration of action is long (up to 48 hours), so they are prescribed for the treatment of high blood pressure in combination with antihypertensive drugs.
- Veroshpiron, spirolactone, triamterene - have a cumulative effect, the result is noticeable only on 2-3 days. These weak diuretics are used in the early stages of hypertension (grade 1) and to enhance the effect of powerful diuretics (in combination with them).
Weak diuretics have another positive quality - they do not remove potassium as actively as other diuretics for high blood pressure.
Interaction
The drug reduces the effectiveness of mitotane , anticoagulants , and increases the effect of antihypertensive and diuretic drugs. Stimulates the effect of Buserelin , Triptorelin , gonadorelin . When taken simultaneously with potassium supplements, the risk of developing hyperkalemia increases. Reduces the toxicity of cardiac glycosides. Indomethacin , salicylates reduce the diuretic effect of the drug. Veroshpiron increases the metabolism of Antipirin and increases the half-life of digoxin .
Analogs
The following drugs can replace verashpirone: spironolactone, inspra or torsemide.
But the specific type of medication, the daily dosage of the drug and the pattern of its use, as well as the method of treatment in case of overdose, are provided only by a specialized doctor.
Video: Veroshpiron instructions
special instructions
Veroshpiron is prescribed in gynecology to reduce androgen levels in women with PCOS ( polycystic ovary syndrome ). The drug can cause bleeding and disrupt the menstrual cycle. Veroshpiron is often recommended to be taken together with contraceptives in order to normalize the menstrual cycle and reduce hirsutism.
Recipe in Latin:
Rp.: Verospironi 0.025 D. td N 20 in tabul. S.
There is no article on the drug in Wikipedia.
Reviews about Veroshpiron
Reviews about Veroshpiron on forums testify in favor of this drug. The medicine is effective, but it is advised to use it in moderation and as prescribed by a doctor, since the drug has side effects and contraindications.
Diuretic tablets fully cope with their assigned function, and also effectively help against edema. In gynecology, the drug is successfully used for skya.
Veroshpiron also helps for weight loss, as it has a diuretic property.
Those who have used the medication claim that it does not help with hirsutism.
Conclusion
For people with diseases of the cardiovascular and urinary systems, the question of which is better for edema is Veroshpiron or Furosemide. Unfortunately, without the results of a medical examination, it is impossible to say for sure which diuretic is best for each individual person. The choice of a drug by a doctor depends on the clinical diagnosis, the age of the patient, as well as the general condition of the person and the presence of concomitant diseases of organs and systems. If the patient needs to quickly remove excess fluid from the body, then he is recommended to use the tablet dosage form of the drug Furosemide.
If the disease involves long-term use of diuretics, then doctors try to prescribe Veroshpiron. Since this drug has potassium-sparing properties, its long-term use will not lead to the development of convulsive syndrome and will not affect the condition of the cardiovascular system.
In gynecological practice, Veroshpiron is often prescribed, since this drug reduces the concentration of testosterone in the female body, thereby normalizing the ovarian-menstrual cycle. It is important to remember that uncontrolled use of Veroshpiron can lead to the development of impotence and gynecomastia in men. It is also prohibited to use Furosemide and Veroshpiron together without prior medical consultation.
In combination with anti-inflammatory drugs and diet, diuretics are used for ascites. These are remedies that significantly relieve symptoms, although they do not remove all excess fluid from the abdomen.
For a complete recovery, it is necessary to cure the disease - the root cause of dropsy. The choice of diuretics depends on the underlying cause.
There are many types of diuretics, the main thing is to make the right choice
Veroshpiron price, where to buy
The price of Veroshpiron in tablets is 75 rubles for 20 pieces.
Capsules can be bought for 160 rubles for 30 pieces of 50 mg and for 250 rubles for 30 pieces of 100 mg.
How much does the drug cost in Ukraine? The price of Veroshpiron in Kharkov is on average 100 UAH for 20 tablets of 25 mg.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Veroshpiron capsules 50 mg 30 pcs. JSC "Gedeon Richter-RUS"
174 rub. order - Veroshpiron capsules 100 mg 30 pcs. JSC "Gedeon Richter-RUS"
RUB 279 order
- Veroshpiron tab. 25 mg No. 20 JSC "Gedeon Richter-RUS"
78 RUR order
- Veroshpiron tab. 25 mg No. 20 JSC Gedeon Richter/Gedeon Richter-Rus JSC
92 rub. order
Pharmacy Dialogue
- Veroshpilakton (Veroshpiron) (caps. 100 mg No. 30) Obolenskoye pharmaceutical pred.
250 rub. order
- Veroshpiron tablets 25 mg No. 20Gedeon-Richter
79 RUR order
- Veroshpilakton (Veroshpiron) capsules 50 mg No. 30Obolenskoye pharmaceutical pred.
RUB 183 order
- Veroshpiron capsules 50 mg No. 30 Gedeon-Richter
RUB 191 order
- Veroshpilakton (Veroshpiron) tablets 25 mg No. 20Obolenskoye pharmaceutical pred.
70 rub. order
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Pharmacy24
- Veroshpiron 50 mg No. 30 capsules VAT "Gedeon Richter", Ugorshchina
97 UAH. order - Veroshpiron 25 mg N20 tablets AT"Gedeon Richter"/TOV "Gedeon Richter Poland", Ugorshchina/Poland
34 UAH order
- Veroshpiron 100 mg No. 30 capsules VAT "Gedeon Richter", Ugorshchina
135 UAH order
PaniPharmacy
- Veroshpiron tablets Veroshpiron tablets 25 mg No. 20 Hungary, Gedeon Richter
34 UAH order
- Veroshpiron capsule Veroshpiron caps. 100 mg No. 30 Hungary, Gedeon Richter
138 UAH order
- Veroshpiron capsule Veroshpiron caps. 50 mg No. 30 Hungary, Gedeon Richter
100 UAH order
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