Glevo for prostatitis: instructions for use

Cutting pain in the lower abdomen and difficulty urinating may be symptoms of cystitis, an inflammatory process of the bladder mucosa.

Due to the anatomical features of the genitourinary system, women are more likely to suffer from cystitis. According to statistics, the percentage of manifestations of the disease in the fair half of humanity reaches 70% per year. Whereas for men it reaches only 8-10%.

The most likely cause of the disease is infection. Pathogenic bacteria and fungi can enter the bladder from the urethra or descend from the kidneys. Cystitis often results from gynecological or inflammatory diseases in other organs.

Treatment of cystitis requires proper treatment. Prescriptions should be made by a doctor after a thorough examination and identification of the causative agent of the disease. First of all, the treatment process involves the use of antibiotics to block the destructive effects of bacteria. Among the drugs used for cystitis, levofloxacin is very popular.

As a rule, cystitis is caused by various infections, so levofloxacin is an effective treatment for this disease

Instructions for use

The first thing patients who are faced with manifestations of cystitis need to remember is that self-medication is dangerous to health. Antibiotic therapy can only be prescribed by a doctor, who should be contacted immediately at the first symptoms, which include:

• false urge to urinate up to 30 times per day;
• difficulty releasing fluid (small drops), accompanied by pain and pain in the urethra;
• pain above the pubis and in the lower back;
• change in the color and smell of urine (the color is cloudy and dark, the smell is sharp and unpleasant);
• the presence of bloody impurities and clots in the urine;
• no feeling of emptiness after visiting the toilet;
• general malaise, manifested by loss of appetite, headache and low-grade body temperature.

The dosage and form of the antibiotic is determined by the urologist . Tablets are the preferred dosage form, because infusions are prescribed to people in more severe conditions in whom cystitis is a concomitant disease.

Drink 1-2 Levofloxacin tablets per day with plenty of water.

The daily dosage should be 250 mg for both uncomplicated and complicated urinary tract infections.

There is no need to tie the medication to meals.

For patients suffering from liver problems, no special selection of daily dosage is made, since levofloxacin does not have a negative effect on the organ. People undergoing outpatient or single hemodialysis do not receive additional doses.

pharmachologic effect

Belongs to the group of fluoroquinolones. The medication has bactericidal and antimicrobial properties. The mechanism of action of any dosage form is based on the ability of the drug to block DNA gyrase and topoisomerase IV. Under the influence of the drug, disruption of supercoiling and cross-linking of DNA breaks, acceleration of morphological changes in cell walls, membrane and cytoplasm are observed.

The active ingredients in the drug are active against a number of gram-positive, gram-negative and anaerobic strains of microorganisms. These include:

• Staphylococcus spp.;
• Enterococcus spp.;
• Acinetobacter spp.;
• Citrobacter freundii;
• Pasteurella dagmatis;
• Bacteroides fragilis;
• Chlamydia pneumoniae;
• Mycobacterium spp.

With long-term use, the medicine does not reduce the sensitivity of the suspected pathogen; there is no resistance. The medication is effective even if the bacteria develop polymorphically.

Pharmacokinetics is linear. Any dosage form is quickly absorbed from the upper intestines. The rate of absorption does not depend on the presence of food in the stomach. The bioavailability of the tablet form is high, more than 98%.

The binding of the active element to blood proteins is insignificant - about 40%. The drug quickly penetrates into the soft tissues of internal organs. The half-life is 60 minutes and is metabolized by the liver. Has no active metabolites. The medication leaves the body with urine, no more than 3% is excreted from the body with feces.

Duration of admission

Often the course of antibiotic does not exceed 7–10 days . It is important to remember that even after the onset of visible relief and normalization of body temperature, you cannot stop taking it. Even after receiving positive laboratory test results, it is recommended to continue treatment for another 24-48 hours.

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A little about prostatitis

The prostate, located around the circumference of the urethra, is considered the main male organ. The prostate gland is designed to produce sperm and obstruct the flow of urine into the urethra during erection.

Prostatitis is a disease with an inflammatory course in the prostate gland inevitably leads to:

• urinary disorders;
• incomplete emptying of the bladder;
• painful, frequent urge to go to the toilet;
• special discomfort in the pubic area and perineum.

In chronic prostatitis, a painful symptom is clearly expressed. Other accompanying symptoms are often associated with the acute form of the disease:

Anatomy of the genitourinary system

• weakness;
• malaise;
• aches in muscles, joints;
• temperature increase.

Unpleasant signs cause men physiological and psychological discomfort, lead to disorders in the sexual sphere and greatly worsen the quality of life.

Contraindications

The first prohibition for use is the age of patients under 12 years. Further, the list of contraindications includes:

• pregnancy and lactation;
• renal failure;
• convulsive and fainting conditions caused by epileptic seizures;
• allergic reactions to fluoroquinolone antibiotics;
• allergic reactions to individual components of the drug;
• tendon damage due to quinolones.

The last point is one of the main side effects that can be observed during treatment with Levofloxacin. In addition, the following manifestations are not uncommon:

• digestive disorders;
• headache;
• skin rashes and itching;
• thrush.

Pharmacodynamics

Glevo is an antibiotic that acts on gram-positive and gram-negative bacteria. Release form: biconvex round tablets in blisters (cardboard packaging). Active ingredient – ​​Levofloxacin, auxiliary components: povidone, microcrystalline cellulose, magnesium stearate, macrogol, hypromellose, red iron oxide, talc.

The active substance in the drug Glevo promotes:

Active remedy

• rupture and suppression of DNA synthesis;
• morphological modifications in the cytoplasm and walls of cellular bacteria.

The drug is completely absorbed from the intestines. Bioavailability – 99%. The maximum concentration in the blood is observed 2 hours after taking the tablet. The active substances quickly penetrate the organs and tissues of the alveolar bronchi mucosa, and then into the genitourinary system. Oxidation (desocialization) occurs by liver cells. The half-life directly by the kidneys is up to 8 hours.

Similar drugs

Levolet

Nolitsin
Medicines similar in composition and principle of action include:

• " Levolet ". An antimicrobial agent with a bactericidal effect, Levolet is taken orally, topically and intramuscularly. For cystitis, take 250 mg once a day for 7–10 days. Price: 360 rubles for 10 tablets.
• " Nolitsin ". This medication contains norfloxacin, to which most bacteria are sensitive. The course of treatment with Nolitsin for urinary tract infections takes from 3 to 5 days, during which they take 400 mg 2 times a day.

Levolet (500 mg)

Film-coated tablets 250 and 500 mg

Compound

One tablet contains

active substance – levofloxacin hemihydrate 256.233 mg and 512.466 mg

excipients: microcrystalline cellulose (Avicel RN 101), microcrystalline cellulose (Avicel RN 102), corn starch, crospovidone, hypromellose 15 cps, colloidal silicon dioxide (Aerosil 200), magnesium stearate,

shell composition: opadry white OY 58900, hypromellose 5 cP, titanium dioxide E 171, macrogol/PEG 400, purified water

Description

White, capsule-shaped, film-coated tablets with a biconvex surface engraved “DRY” on one side and “279” on the other (for a dosage of 250 mg).

White, capsule-shaped, film-coated tablets with a biconvex surface engraved “DRY” on one side and “280” on the other (for a dosage of 500 mg).

Pharmacotherapeutic group

Antimicrobial drugs are quinolone derivatives. Fluoroquinolones. Levofloxacin.

Code ATXJ01MA12

Reviews and survey

Does Levofloxacin help with cystitis?

Most reviews from patients who have taken the medication are positive. Thus, a man suffering from chronic inflammation of the bladder left a positive review of Levofloxacin on one of the popular forums, emphasizing its effectiveness and speed.

Women suffering from cystitis caused by the activity of harmful microorganisms note that after treatment with these medications, there is practically no relapse of the disease

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Glevo® analogues

• Ivacin® (from 170 to 240 rubles)
• Levolet® (from 210 to 550 rubles)
• Levofloxabol® (from 360 to 500 rubles)
• Levofloxacin® (from 270 to 600 rubles)
• Maklevo® (from 350 to 510 rubles)
• Oftaquix® (from 220 to 300 rubles)
• Remedia® (from 200 to 600 rubles)
• Signicef® (from 230 to 390 rubles)
• Tanflomed® (from 350 to 510 rubles)
• Hyleflox® (from 320 to 1090 rubles)
• Ecolevid® (from 310 to 690 rubles)

As for the cost of Glevo® 500 itself, 5 tablets will cost 180 rubles, 10 pcs. - 360 rubles, and 25 pcs. – at 820 rub.

Non-surgical methods for treating hydronephrosis

Before starting treatment for hydronephrosis, it is necessary to understand that this is a pathological condition leading to gradual expansion of the kidney, atrophic phenomena and the development of renal failure due to acute or gradual disruption of the outflow of urine. Among the many causes of hydronephrosis, most often it occurs due to urolithiasis, namely the presence of a calculus of the ureter or pyelocaliceal system of the kidney, the latter completely or partially blocking their lumen. As a result, such processes lead to the fact that a person needs radical surgery, the plastic surgery of which saves his life.

How to treat hydronephrosis? What treatment options are most effective?

Indications for surgical treatment

It should be noted that surgery for hydronephrosis is performed in the following cases:

• compression of the ureter from the outside (tumor of surrounding tissues and organs, aneurysm of the abdominal aorta, as well as both iliac vessels, etc.);
• a kidney tumor growing into the calyx, pelvis or into the lumen of the ureter;
• anomalies in the development of the urinary system (plasticity of the elements included in this anatomical region is necessary);
• coral kidney stones (kidney resection or kidney grafting);
• hydronephrosis of the third or fourth stage;
• stricture of the ureter both along its entire length and in a certain area (plasty of this anatomical formation is the operation of choice);
• prostate adenoma, compressing the distal parts of the ureter;
• trauma to the ureter with damage to its wall or the renal collecting system (plasty is an unconditional method of treatment).

In all cases not mentioned above, hydronephrosis can be treated with conservative and folk remedies, or at least compensate for the disorders caused by this pathology. Conservative therapy for hydronephrosis is used in cases where the patient simply cannot tolerate surgery (especially if plastic surgery or reconstruction of the genitourinary system is performed) due to serious metabolic complications or general condition.

Conservative therapy

Conservative methods of treating hydronephrosis are performed as an alternative to surgery or are used in the postoperative period. The main goal is the treatment of concomitant disorders in the body. Or in the case of urolithiasis, when a stone has blocked the lumen of the ureter, relieving the patient of pain and restoring normal urine passage. As well as treatment and prevention of infectious complications caused by stagnation.

Among the main objectives of conservative treatment of hydronephrosis, the following should be highlighted:

1. Treatment of pain associated with a block of the renal collecting system or ureter. This goal is achieved by painkillers (analgesics), and their various groups (non-narcotic and narcotic). These drugs are selected depending on the severity of pain, general condition (blood pressure, respiratory rate, presence or absence of consciousness) and resistance (sensitivity) to them. It should be added that kidney pain can be so severe that a combination of both is necessary. Typically, this condition occurs with oncology or renal colic. The most commonly used are opioid analgesics (Tramadol, Butorphanol, Omnopon, Promedol, Morphine hydrochloride), as well as non-steroidal anti-inflammatory drugs or COX 2 receptor inhibitors (Movalis, Dexalgin, Ketanov, Analgin, Dicloberl, Ibuprofen and others). It is important to note that it is necessary to be attentive to the relief of pain with such drugs, since the latter, at high dosages, significantly affect the function of the kidneys and liver.
2. Reducing spasm of blood vessels and ureter. The effect is achieved by antispasmodics, which promote relaxation and expansion of the walls of these anatomical structures, which leads to the restoration of the passage of urine and blood. These drugs include: No-shpa, Papaverine, Spazmolgon, Baralgetas, Riabal, Magnesia 25%, Eufillin.
3. Reduced inflammation in the kidney parenchyma. For this purpose, combined herbal preparations are used in the form of a solution or capsules. The modern pharmaceutical market is represented by the following drugs: Urolesan and Canephron. These drugs, in addition to relieving inflammation, also have a bacteriostatic effect.
4. Treatment and prevention of infectious complications that arise due to stagnation of urine and the proliferation of microorganisms in it. This is achieved with broad-spectrum antibacterial agents and uroseptics (Ceftriaxone, Cefazolin, Cefoperazone, Levofloxacin, Moxifloxacin, Nitroxoline, Palin).
5. Improving microcirculation in the renal parenchyma. Alternatively, you can use antiplatelet agents (Pentoxifylline, Trental, Tivortin).
6. Treatment of the liver, since it and the kidneys participate in cleansing the body, and if the functions of the latter are impaired, the liver takes on all the work. To protect it and enhance the detoxification function, medications supplemented with folk remedies are used. The first include Essentiale, Heptral, Antral, Alohol, Hofetol, and the second include rosehip.
7. In the last stage of hydronephrosis and due to the occurrence of renal failure, hemodialysis is performed regularly. In this case, only it helps the body get rid of protein breakdown products.

ethnoscience

Treatment of hydronephrosis with folk remedies is used as an additional method, but cannot be the main one, since it does not significantly affect the condition of the genitourinary system. It is important to understand that such treatment should last for at least six months. Before starting activities, it is imperative to consult with a nephrologist or urologist.

The most suitable folk remedies for the treatment of hydronephrosis are special kidney teas, which include: chamomile, calendula, birch, adonis, peppermint, lemon balm, pine needles, rose hips, string, dandelion, oregano. In various combinations, these herbs have antispasmodic, diuretic and antiseptic effects.

It is also necessary to understand that treatment of hydronephrosis with folk remedies can cause a severe allergic reaction, since ready-made teas contain many herbs. Therefore, it is important to begin treatment under the supervision of a doctor and gradually in small portions. All other folk methods presented on the Internet are not a panacea and can threaten the health of a sick person.

Nutrition for hydronephrosis

Nutrition is also regarded as one of the types of treatment for hydronephrosis. Diet table No. 7 is considered the most acceptable. The diet almost completely excludes table salt, animal protein and fats, compensating for this with fruits and vegetables. The diet significantly reduces daily caloric intake and fluid volume.

Which is better: Glevo or Tavanik

Both drugs are analogues of each other. Active ingredient in the drug: Levofloxacin. Tavanika release form: film-coated tablets, solution for infusion. Glevo is produced only in the form of film-coated tablets. Both drugs are prescribed by a doctor after a medical examination. The country of origin of the drug Tavanic is Switzerland. Glevo is produced in India. In terms of cost, Tavanic is more expensive than the antibiotic Glevo.

Tavanik. Photo: apteka.uz