Cystitis requires immediate and radical treatment, since the disease can enter the chronic phase of development. The use of Norfloxacin for cystitis can be considered as one of the options for solving the problem. After all, this antimicrobial agent is capable of suppressing the vital activity of most gram-positive and gram-negative microorganisms, which cause inflammation in the bladder. It is worth familiarizing yourself with the pharmacological action of the drug, as well as the features of its use.
Compound
The main active element is norfloxacin . In tablets and capsules it is contained in a concentration of 200 or 400 mg. Additional components are dibasic calcium phosphate, lactose, corn starch, sodium benzoate, gelatin, magnesium stearate, talc, colloidal silicon anhydride, methylene chloride, sodium starch glycolate and dye.
Antibacterial drops for eyes and ears contain, in addition to norfloxacin, disarium edetate, acetic acid, benzalkonium Cl, sodium chlorine, and water for injection.
Indications for the use of Norfloxacin, reviews of use
"Norfloxacin" has a bactericidal and antimicrobial effect against some gram-positive bacteria and most gram-negative bacteria. According to reviews, the drug is effective for diseases of the urinary tract (pyelonephritis, cystitis, urethritis), shigellosis, salmonellosis, cervicitis, prostatitis, endometritis, gonorrhea. It is prescribed as a preventive measure for the recurrence of urinary tract infections, bacterial infections in granulocytopenia, and “travelers’ diarrhea.” Externally, "Norfloxacin" is used for corneal ulcers, keratitis, conjunctivitis, keratoconjunctivitis, blepharitis, for the prevention of eye infections after removal of a foreign body, infectious complications after surgical operations on the hearing organs, for chronic and acute otitis media.
Analogues of “Norfloxacin”: “Nolitsin”, “Lokson-400”, “Sofazin”, “Norilet”, “Norfatsin”, “Norbaktin”.
How Simply Recommends
Why the medicine doesn’t work The key to successful treatment is, of course, following all the doctor’s recommendations and informing him of all significant changes during therapy. However, a specialist can talk as much as he wants about the regimen and duration of taking the drug, but most patients will still violate these rules. Read more
According to reviews, Norfloxacin sometimes causes problems with the digestive system. Diarrhea, heartburn, bitterness in the mouth, decreased appetite, abdominal pain, vomiting, and nausea appear. "Norfloxacin" can cause crystalluria, glomerulonephritis, dysuria, polyuria, albuminuria, urethral bleeding, headache, insomnia, arrhythmia, dizziness, tachycardia, fainting, decreased blood pressure, hallucinations, candidiasis, allergic reactions (skin itching, swelling, urticaria) .
Effect of the drug on cystitis
Norfloxacin is absorbed into the intestines and stomach. Absorption of the dose taken is 40%. An additional barrier to absorption is created by undigested food in the stomach.
The maximum concentration of the substance, which is sufficient to suppress existing pathogenic microorganisms and their reproduction, is achieved an hour after drinking the tablet. The effect on cystitis is due to the fact that norfloxacin destroys the structure of the DNA chain in pathogen cells. The drug is excreted in bile and urine.
Contraindications
The antibiotic Norfloxacin is not prescribed if the following contraindications are established:
- a person cannot tolerate certain components of the product, which can cause a variety of allergic reactions;
- with the development of tendonitis, since the remedy can lead to tendon rupture;
- components are difficult to break down if the body produces insufficient amounts of glucose-6-phosphate dehydrogenase enzyme;
- the medication poses a threat to the patient’s life in cases where the muscles of the respiratory system become pathologically tired under the influence of the active substance;
- with dysfunction of blood circulation in the brain structures of the head;
- with the development of epileptic manifestations;
- childhood and adolescence, because the active substance norfloxacin contributes to the occurrence of joint pathological conditions in children;
- with the development of renal and liver failure;
- pregnancy and lactation period.
Instructions for use and dosage for cystitis
To get rid of the symptoms of inflammation of the bladder, use the tablet form of Norfloxacin. If cystitis is uncomplicated, then the antibiotic should be taken every 12 hours at a dosage of 400 mg for three days.
If the course of the disease is complicated, then the course is extended to 10-20 days .
Chronic cystitis is treated for a long time – up to three months. In this case, at first they drink 800 mg per day, and after improvements the dosage is reduced by half. For prophylactic purposes, it is recommended to take 200 mg of norfloxacin per day. If a person is diagnosed with kidney problems and creatinine clearance is below 20 ml/min, it is worth using half the therapeutic dosage twice a day.
Side effects
It is imperative to consult a doctor in a special medical institution, because the use of Norfloxacin can cause a large number of different unpleasant effects:
- headache and dizziness;
- the patient feels nauseous, which may lead to vomiting;
- diarrhea or, conversely, constipation;
- disturbance of the intestinal microflora;
- there is bloating in the abdomen;
- development of hyperfunctionality of liver enzymes;
- change in urea composition;
- kidney dysfunction;
- the occurrence of dysuria;
- Sometimes there may be bleeding in the urethra;
- disruption of sleep processes;
- toxic psychotic states develop in the form of hallucinations;
- the occurrence of convulsive syndrome, hand tremors is observed;
- tachycardia is troubling;
- the pressure in the artery works intermittently, after a few minutes changing from high to low and vice versa;
- the development of an inflammatory process is observed in the vascular system;
- the number of leukocytes decreases (the occurrence of leukopenia);
- damage to bones and ligaments in elderly people. After taking the drug, patients may experience tendon rupture. If pain occurs in the muscles, stop taking the pills. In this case, you should move limitedly until the person’s health is completely restored;
- this antibiotic can cause the development of various allergic reactions. The patient may experience itching-like sensations, hives or redness of another nature may be observed on the skin;
- Sometimes after using the tablets, patients developed anaphylactic shock and collapse of the heart muscle.
To reduce the risk of developing unpleasant consequences for the human body, you need to consult with your doctor whether Norfloxacin tablets can be taken. He will conduct a full examination, on the basis of which the possibility of using the product will be determined.
If you experience any side effects after taking this honey. means, you must immediately stop using the pills and consult a doctor for advice. A specialist can conduct a full examination and recommend a substitute with a similar composition that is not capable of causing negative consequences for human health.
Analogs
There are many substitutes for Ofloxacin available for free sale through the pharmacy chain, which in terms of pharmacological properties are equivalent to this antibiotic. All of them contain a similar active substance. The list of most commonly prescribed drugs includes:
Due to the existing differences between them, the doctor chooses the most suitable one. A similar medication may be prescribed if the first one is ineffective or if any of its components are intolerable.
Ofloxacin and its analogues
The production of Ofloxacin analogues is established by manufacturers of well-known domestic and foreign companies - Japan, the USA, Eastern and Western Europe.
Prices for domestic analogues - “Ashof”, “Vero-Ofloxacin”, “Glaufos”, “Dancil”, “Geoflox” with various dosages fluctuate in the pharmaceutical network from 24 to 156 rubles.
- “Zanocin” - from 176 to 273 rubles;
- "Zanocin OD" from 310 rub.
- “Oflo”, “Oflox”, “Ofloxabol”, “Ofloxacin SOLOpharm”, “Ofloxacin DS”, “Tariferid” “Taricin” “Uniflox” - from 42 rubles. up to 370 rubles.
"Zoflox" - from 200 to 220 rubles.
"Ofloxacin Zentiva", "Ofloxacin Protech", "Ofloxacin Sandoz", "Ofloxacin STADA", "Ofloxacin (Ofloxacin)", "Ofloxacin-OBL", "Ofloxacin-Promed", "Ofloxacin-Teva", "Ofloxacin-FPO", “Oflomak”, “Oflocid forte”, “Roflo” - from 170 to 220 rubles.
Numerous studies on the use of Ofloxacin in the treatment of cystitis have shown the effectiveness of the drug. With timely initiation of treatment with this drug, further spread of infection and relief of pathological symptoms is achieved in the shortest possible time after the start of treatment.
Pregnancy, lactation, childhood: features of administration
There have been no comprehensive studies of the effect of Norfloxacin (in the form of tablets and drops) on pregnancy processes. If there is an opportunity to prescribe another, safer and more reliable drug, it is better to use it. If for any reason it is necessary to take Norfloxacin, the patient’s condition should be carefully monitored during treatment.
There is also no sufficient data on the ability of the active substance to penetrate into mother's milk. After taking low doses, the drug is not detected in milk. However, it is necessary to take into account the effect of substances of the quinolone group related to Norfloxacin. They can pass into milk and cause serious problems in nursing infants. For the safety of babies, it is recommended to stop lactation during treatment. If possible, use Norfloxacin in the form of drops.
There are also no statistics on the effect of the drug on children and adolescents. But there are results of laboratory experiments on animals. Of course, a complete analogy cannot be made, but it should be borne in mind that the active substance can cause joint pathologies in immature animals.
The same experiments established that the drug does not affect fertility in animals, but can cause embryo lethality (miscarriages) in monkeys if the recommended dose is exceeded.
Drug interactions
Norfloxacin:
- Increases the concentration of Theophylline in the blood.
- When administered simultaneously with cyclosporines, it increases the concentration of creatinine in the blood serum.
- Strengthens the anticoagulant (anti-clotting) effect of Warfarin.
- May cause severe hypotension when administered concomitantly with antihypertensive drugs.
- Reduces the effect of drugs from the nitrofuran group.
- Slows down the period of caffeine removal from the body.
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Antacids (Almagel, Gastal), as well as drugs that contain calcium, zinc, iron salts, reduce the absorption of Norfloxacin. Therefore, the interval between taking Norfloxacin and antacids should be at least 2 hours.
When prescribing Norfloxacin simultaneously with hypnotics of the barbiturate group, as well as with anesthetics, it is necessary to monitor blood pressure, pulse rate, and electrocardiogram parameters.
When using the drug together with Theophylline and non-steroidal anti-inflammatory drugs, the risk of convulsions and epileptiform seizures increases.
Overdose
Norfloxacin is a fairly strong antibiotic that should be used not only in accordance with the instructions for use, but also as prescribed by the attending physician. It is not recommended to use this drug on your own, since the dosage and treatment period must be selected individually in each case.
If the drug is prescribed incorrectly, a person may experience signs of dizziness, vomiting, convulsions, and nausea. If such symptoms appear, you must immediately stop taking the medication and be sure to rinse your stomach or induce vomiting.
Description
Before taking Norfloxacin, you should consult a doctor for advice, as this medication can cause negative consequences for the human body.
This antibiotic for cystitis must be prescribed in a certain dosage, which is determined on the basis of tests and a number of studies. The body absorbs less than half of the active substance, the rest is quickly excreted through the gastrointestinal digestive tract, kidneys and outer integument. The drug reaches the required concentration for cystitis in men and women within an hour. It is through this period that the active substance destroys the structural integrity of the LNA chain inside pathogenic bacteria.
Norfloxacin is one of the most highly active medications, which eliminates pathologies of the genitourinary system for a short time.
This antibiotic for cystitis destroys pathogenic microorganisms that cannot be eliminated after using other antibiotic drugs. Typically, for cystitis symptoms, it is recommended to take medication in tablet form.
