The cause of elevated leukocytes in a smear in women
An infection or inflammatory process in the genitourinary organs is always accompanied by an increase in leukocytes in a woman’s smear. The reason for the increase in their level may be hidden in various diseases:
- inflammation - appendages (adnexitis), uterine mucosa (endometritis), urethra (urethritis), cervical canal (cervicitis), vagina (colpitis);
- benign and malignant tumor formations of the genitourinary area;
- STDs – syphilis, trichomoniasis, gonorrhea, chlamydia or others;
- dysbacteriosis – vagina or intestines;
- systemic diseases;
- hormonal imbalance.
Deviations from the norm in the analysis of leukocytes can be associated with frequent stress, chronic fatigue, long-term use of antibiotics and other medications.
Sometimes active sexual life leads to a moderate increase in white blood cells in a smear - up to 25 cells.
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Traditional methods of treatment cannot be a complete replacement for medications, but are often used as an adjuvant.
A decrease in the level of leukocytes is facilitated by:
- Douching. To douche, you will need a tampon: a sterile bandage rolled into a tight roll. Using a tampon, the treatment solution is injected into the vagina. You can use a decoction of chamomile or calendula as a solution. Pour 200 ml of boiling water over a tablespoon of finely chopped dry herb, cover with a lid and leave until it cools completely. Strain the finished broth. Before inserting into the vagina, it is advisable to warm the broth to a comfortable warm temperature in order to avoid unpleasant sensations;
- Baths. A medicinal bath is useful as a disease prevention, and during the treatment process it is used as a stimulant. To prepare a bath you will need 20 g of dry laurel leaves. They need to be poured with a glass of boiling water, strained and the broth diluted in 10 liters of water. The water will cool down quickly, but do not add more. This will disrupt the concentration of the decoction, so this bath should be taken no longer than 10 minutes;
- Decoctions for oral administration. A woman can obtain the normal level of leukocytes in a smear corresponding to the one indicated in the table using herbal decoctions. A decoction of St. John's wort has proven itself well. Pour boiling water over 1 teaspoon of dry herb and leave covered for 15 minutes. The prepared decoction is taken 3 times a day. The duration of the course of treatment is 10 days, if necessary repeated after a break of 1 week.
Leukocytes during pregnancy
The norm of leukocytes in a smear in pregnant women is 15-20 cells per field of view.
During pregnancy, the woman is tested several times - the first at the earliest stages during registration. A high level of leukocytes in this case can indicate both an acute pathological process and the presence of a latent infection, which worsened after pregnancy.
Most often these are inflammatory diseases caused by STDs, or thrush (candidiasis). After an accurate diagnosis, local treatment is prescribed, and if it does not have an effect, then antibiotic therapy or other methods are selected, depending on the duration.
Indications for the study
To diagnose and analyze possible female diseases, a smear test is taken:
- It must be taken if any abnormalities occur in the menstrual cycle.
- You should also be concerned about pain in the lower abdomen and discomfort during sex.
- An indication for testing for elevated white blood cells is painful urination, which is accompanied by a burning sensation in the urethra.
- In patients who have taken hormonal drugs and antibiotics, a smear is also taken to detect elevated leukocytes.
- As for pregnancy, the analysis is mandatory at the first time a woman contacts her. If no deviations are found, then the next smear from the urethra is taken at a later date.
- In the absence of any suspicious symptoms, women are still recommended to undergo such an examination at least once every 3 months, since most pathologies in the early stages are asymptomatic.
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Leukocytes in a smear - the norm in women (table), causes of elevated leukocytes
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In gynecological practice, this diagnostic method, such as a smear, is used very widely and is used frequently. This is one of the main standard procedures that helps assess the condition of the reproductive system organs in women.
Of course, absolutely all pathologies cannot be identified using this diagnostic method, but at least many of them can be suspected based on the smear results. That is why analysis is paramount: it allows you to determine the course of further diagnostics and select more in-depth and informative research methods.
What do you pay attention to when deciphering an analysis?
Smear analysis allows you to evaluate the following indicators: leukocytes, squamous epithelial cells, key cells, mucus in the biomaterial, as well as the content of normal, pathogenic and opportunistic flora. The last category includes yeast of the genus Candida. Among pathogenic microorganisms, trichomonas and gonococci can be detected using a flora smear.
A very important diagnostic indicator is the leukocyte count. These cells of the immune system protect the body from foreign agents, whether microorganisms or destroyed or altered structural elements.
It is leukocytes or white blood cells that rush to the pathological focus of inflammation in the body, wherever it is. And if pathology develops in the organs of the reproductive system, these cells will go there.
In women, leukocytes are always present in a smear for flora, and their norm is a rather arbitrary concept. The fact is that in different parts of the genitourinary system their permissible values differ. Most white blood cells are in the cervical area; their lowest content is normally observed in the urethra.
However, to diagnose inflammatory processes, it is important to evaluate not so much the number of leukocytes as their morphology. This is due to the fact that white blood cells, which have fulfilled their function of “cleansing” the body of pathogens, are destroyed. Such leukocytes are called neutrophils.
- Accordingly, the more of them in the smear, the stronger the inflammatory reaction.
In addition, it is important to take into account the fact that the concentration of white blood cells during the menstrual cycle changes under the influence of sex hormones, so if the leukocytes in the smear are slightly elevated, this is not necessarily a sign of a serious pathology.
In any case, the content of these cells should be assessed only in conjunction with other diagnostic criteria: the composition of normal flora and opportunistic microorganisms, the presence or absence of pathogenic bacteria, the number of epithelial and key cells.
Types of epithelial cells
There are several types of epithelial tissue:
- Single layer
. It can be divided into several more: flat, edged, cylindrical and cubic; - Multilayer
. This type includes flat keratinized or non-keratinized, glandular, transitional and, quite rarely, cubic and cylindrical.
Doctors and various laboratories most often use the term “squamous epithelium”. Using an analysis of the quantitative content of epithelial tissue in a smear or urine, the doctor can draw appropriate conclusions about the patient’s health and give the necessary recommendations for treatment. There are certain standards; in a healthy person, the content of squamous epithelium is within certain permitted values. A significant increase in indicators indicates a progressive course of the inflammatory process, which means that prompt therapeutic intervention is required.
Norm of leukocytes in a smear in women (table)
As noted above, diagnostic material for a smear on the flora is collected from three points - the cervix, urethra and vagina.
And in each smear obtained, similar indicators are assessed, but the norms of some of them differ depending on the area of localization.
Below is a table explaining the normal content of leukocytes, normal and pathogenic flora, cellular elements and mucus in a smear in women. Diagnostic criterion
Normal indicators | |||
Vagina (V) | Cervix (C) | Urethra (U) | |
Leukocytes (Le) | 0-10 | 0-30 | 0-5 |
Slime | moderately | — | |
Epithelial cells | 5-10 | ||
Key cells | — | — | — |
Microflora | Gram-positive rods (bifido- and lactobacilli) ++++ | — | — |
Yeast (Candida) | — | — | — |
Trichomonas (Trich) | — | — | — |
Gonococci (Gn) | — | — | — |
A smear that fully corresponds to the normal parameters is a rather rare phenomenon. However, minor deviations from the norm are allowed when it comes to the vagina. The urethra and cervix, if there are no pathologies, must be sterile - there should be no microflora there. Regarding the vagina, the situation is ambiguous.
Depending on the content of various microorganisms, there are 4 degrees of purity.
An ideal smear, free of leukocytes and pathogenic flora, corresponds to the first. However, most women cannot boast of such results. Often, individual leukocytes are found in the vaginal discharge within the normal range (up to 10 pcs.), an insignificant content of epithelial cells and opportunistic bacteria. This picture is not characterized as pathological, and the smear belongs to the second degree of purity.
Causes of elevated white blood cells in a smear
If a woman’s smear has elevated leukocytes, the reasons for this are related to inflammatory processes. The greater the concentration of these cells, the more pronounced the process. However, this indicator must be assessed in conjunction with other diagnostic aspects.
For example, an increase in mucus content is observed with the development of infections. This is how the body strives to “cleanse itself” of pathogens. An increase in the number of epithelial cells, as well as leukocytes, warns of inflammation.
According to some laboratories, the content of these elements up to 10 in the field of view is allowed, but this indicator varies depending on the phase of the menstrual cycle and its values should not be interpreted without regard to other diagnostic signs.
Key cells are epithelial cells dotted with Gardnerella bacteria. This is the so-called “bacterial sand”. If such cells are detected in a smear, there is a high probability of developing bacterial vaginosis (gardnerellosis).
A decrease in the content of gram-positive bacilli is possible both during the use of antibiotics and during the development of diseases caused by opportunistic microorganisms. In the first case, taking pre- and probiotics is indicated. In the second, the causative agent of the infection should be identified.
The detection of a large number of candida in a smear against the background of suppression of normal flora is a sign of thrush. This is due to the fact that when the concentration of Doderlein rods, which produce lactic acid, decreases, the pH of the vagina increases.
This condition leads to the active growth of opportunistic flora, including candida. In an acidic environment, these microorganisms cannot reproduce, and thus bifidobacteria and lactobacilli inhibit the process of colonization of the vagina.
Gonococci and Trichomonas are pathogenic microorganisms. Under no circumstances should they be in the smear. The detection of these bacteria signals the development of gonorrhea or trichomoniasis.
Treatment
It is important to understand that when treating abnormal smear values, a targeted fight against the cause of elevated white blood cells is necessary, and not just with bringing their number to normal.
Candles
Candles (suppositories) are used in the treatment of disorders of the female genital organs.
Candles for the treatment of female diseases:
Group | Examples | Doses |
Antifungal (against thrush) | Pimafucin | 1 candle at night, 6‒10 days |
Livarol | 1 candle at night, 6‒12 days | |
Anti-inflammatory | Revmoxicam | 1 suppository 2 times a day, rectally, 5 days |
Dicloberl | 1 suppository once a day, rectally, 5 days | |
Antibacterial | Hexicon | 1-2 suppositories per day, 14 days |
Betadine | 1 candle per day, 7 days | |
Healing | sea buckthorn oil | 1 candle per day, 7 days |
Vagical | 1 suppository per day, 8 days | |
Complex | Terzhinan | 1 capsule intravaginally, 10 days |
Polygynax | 1 capsule intravaginally, 10 days | |
Antimicrobial | Flagyl | 1 candle per day, 10 days |
Trichopolum | 1 tablet per day, 10 days |
Douching
To wash and cleanse the genital areas, douching with miramistin, chlorhexidine, ioddicerin and potassium permanganate solutions is prescribed. This procedure is intended to cleanse and disinfect the vaginal mucosa. Douching is performed 1-2 times a day for 7 days. Douching is contraindicated for pregnant women.
Treatment of external genitalia
For pregnant women, it is allowed to treat the external genitalia with antiseptic agents (furacilin, citeal, chlorhexidine, betadine) after a shower. In addition, there are creams applied externally (Macmiror, Kolpotrofin, Lomexin).
Antibiotics
Antibiotics are used to treat sexually transmitted infections.
Antibiotics for the treatment of female diseases:
A drug | Dose |
Roxithromycin | 150 mg 2 times a day, 7 days |
Doxycycline | 100 mg 2 times a day, 7 days |
Levofloxacin | 500 mg 1 time per day, 10 days |
Josamycin | 500 mg 3 times a day, 10 days |
Immunomodulators
To strengthen the body's immunity, immunomodulators are also prescribed. Immunomodulators for gynecological diseases:
Immunomodulators:
A drug | Dose |
Cycloferon | 3-4 tablets per day |
Viferon | 1 candle 2 times a day, 10 days |
Timalin (injections) | 1 injection once a day, 10 days |
Folk remedies
Gynecological inflammations are also treated with folk remedies. Among them are the following: douching with solutions:
There are also tampons containing mixtures of aloe and honey. However, this type of medication must be used strictly on the recommendation of the attending physician in order to prevent complications.
If sexually transmitted infections are detected, treatment should be prescribed to both partners, otherwise re-infection is possible.
Leukocytes in a smear during pregnancy
Conception triggers a cascade of processes in a woman’s body, and in order for them all to proceed smoothly, the balanced functioning of the endocrine organs that produce hormones is important. Changing their balance causes powerful changes in the functioning of organs and systems.
Thus, sex hormones - progesterone and estrogens - stimulate the work of squamous epithelial cells. They begin to actively synthesize glycogen, which supports the reproduction of normal flora. By destroying this connection, Doderlein's bacilli produce large amounts of lactic acid, which acidifies the environment, and thereby provide protection against infections.
However, given the physiological decrease in immunity during pregnancy, this measure is often not enough. Many expectant mothers, when the balance of hormones changes, begin to suffer from thrush or other pathologies caused by opportunistic microorganisms.
Against this background, an increased content of leukocytes is noted in the smear. Often the concentration of such cells in the vagina of pregnant women exceeds the norm - up to 10 pieces. in one field of view.
- If their content is no more than 15-20, and the expectant mother does not experience any signs of pathology, and the rest of the smear indicators are normal, there is no need to worry.
It is important to note that the concentration of leukocytes in the urethra and cervix should not change. The norms for these indicators are the same as for non-pregnant women. Elevated white blood cells in the urethra are a sign of inflammation. This condition requires diagnosis and treatment.
During pregnancy, the leukocyte count should be monitored especially carefully, since it warns of the manifestation of chronic pathologies. It is better for the expectant mother to undergo an examination once again.
Do I need to prepare in any way?
To obtain reliable analysis results, you must adhere to several recommendations. During the week before the procedure, you should not use ointments, sprays, vaginal suppositories and other medications unless they have been specifically prescribed by your doctor. You should also refrain from sexual intercourse for 2-3 days before visiting a specialist. In the evening before the procedure, wash with warm water without soap; in the morning it is not necessary to undergo this procedure. It is advisable to avoid urinating before taking the test.